Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Epigenetics is the study of heritable alterations in gene expression that are not accompanied
by the corresponding change in DNA sequence. Three interlinked epigenetic processes …

Histone deacetylases are key enzymes of epigenetic regulation and are therefore involved
in crucial cellular events like transcription, differentiation, apoptosis and cell division. The …

Acute myeloid leukaemia (AML) is a heterogeneous disease that is, in general, associated
with a very poor prognosis. Multiple cytogenetic and molecular abnormalities that …

The development of B and T cells from hematopoietic precursors and the regulation of the
functions of these immune cells are complex processes that involve highly regulated …

Acute myeloid leukemia (AML) is the second most common form of leukemia and the most
frequent cause of leukemia-related deaths in the United States. The incidence of AML …

Simple Summary The EZH2-targeted drugs have demonstrated notable therapeutic effects
in EZH2 mutant B-cell lymphoma patients. In this study, we demonstrated that the …

Several new therapeutic strategies are now considered for acute myeloid leukemia (AML)
patients unfit for intensive chemotherapy, including modulation of protein lysine acetylation …

Cell‐penetrating peptides provide a unique platform to create a new generation of cancer
therapeutics with enhanced efficacy and diminished toxicity. In our study, enhanced …

Background Rhabdoid tumors are highly aggressive malignancies affecting infants and very
young children. In many instances these tumors are resistant to conventional type …