Amyloid oligomers: A joint experimental/computational perspective on Alzheimer's disease, Parkinson's disease, type II diabetes, and amyotrophic lateral sclerosis
PH Nguyen, A Ramamoorthy, BR Sahoo… - Chemical …, 2021 - ACS Publications
Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …
Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by
binding to microbial or self DNA in the cytoplasm. Upon binding DNA, cGAS produces …
binding to microbial or self DNA in the cytoplasm. Upon binding DNA, cGAS produces …
Calreticulin and cancer
Calreticulin (CALR) is an endoplasmic reticulum (ER)-resident protein involved in a
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …
spectrum of cellular processes. In healthy cells, CALR operates as a chaperone and Ca2+ …
[PDF][PDF] Phase separation in membrane biology: the interplay between membrane-bound organelles and membraneless condensates
YG Zhao, H Zhang - Developmental Cell, 2020 - cell.com
In eukaryotic cells, various membrane-bound organelles compartmentalize diverse cellular
activities in a spatially and temporally controlled manner. Numerous membraneless …
activities in a spatially and temporally controlled manner. Numerous membraneless …
A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
D Zhang, Y Liu, Y Zhu, Q Zhang, H Guan, S Liu… - Nature cell …, 2022 - nature.com
Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
STING) mechanism surveys microbial invasion and cellular damage and thus participates in …
Archaea and the origin of eukaryotes
Woese and Fox's 1977 paper on the discovery of the Archaea triggered a revolution in the
field of evolutionary biology by showing that life was divided into not only prokaryotes and …
field of evolutionary biology by showing that life was divided into not only prokaryotes and …
[HTML][HTML] Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein: from mechanistic studies to clinical trials for COVID …
An outbreak of novel coronavirus-related pneumonia COVID-19, that was identified in
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
December 2019, has expanded rapidly, with cases now confirmed in more than 211 …
The delivery of therapeutic oligonucleotides
RL Juliano - Nucleic acids research, 2016 - academic.oup.com
The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …
with the approval of the first antisense drug and with promising developments in late stage …
Mechanisms of autophagy initiation
Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …
autophagosome. A range of signaling processes converge on two protein complexes to …