A global view of the interplay between non-alcoholic fatty liver disease and diabetes

N Stefan, K Cusi - The lancet Diabetes & endocrinology, 2022 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …

The complex link between NAFLD and type 2 diabetes mellitus—mechanisms and treatments

G Targher, KE Corey, CD Byrne… - … reviews Gastroenterology & …, 2021 - nature.com
Nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions worldwide.
NAFLD and type 2 diabetes mellitus (T2DM) are known to frequently coexist and act …

Non-alcoholic fatty liver disease: the interplay between metabolism, microbes and immunity

H Tilg, TE Adolph, M Dudek, P Knolle - Nature metabolism, 2021 - nature.com
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

Pathophysiology of type 2 diabetes mellitus

U Galicia-Garcia, A Benito-Vicente, S Jebari… - International journal of …, 2020 - mdpi.com
Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

[PDF][PDF] The role of hepatokines in NAFLD

N Stefan, F Schick, AL Birkenfeld, HU Häring, MF White - Cell metabolism, 2023 - cell.com
Non-alcoholic fatty liver disease (NAFLD) is not only a consequence of insulin resistance,
but it is also an important cause of insulin resistance and major non-communicable diseases …

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

M Dudek, D Pfister, S Donakonda, P Filpe, A Schneider… - Nature, 2021 - nature.com
Nonalcoholic steatohepatitis (NASH) is a manifestation of systemic metabolic disease
related to obesity, and causes liver disease and cancer,. The accumulation of metabolites …

Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics

P Morigny, J Boucher, P Arner, D Langin - Nature Reviews …, 2021 - nature.com
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …

Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity

AD Hildreth, F Ma, YY Wong, R Sun, M Pellegrini… - Nature …, 2021 - nature.com
White adipose tissue (WAT) is an essential regulator of energy storage and systemic
metabolic homeostasis. Regulatory networks consisting of immune and structural cells are …

Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies

S Schlesinger, M Neuenschwander, J Barbaresko… - Diabetologia, 2022 - Springer
Aims/hypothesis The term prediabetes is used for individuals who have impaired glucose
metabolism whose glucose or HbA 1c levels are not yet high enough to be diagnosed as …

[HTML][HTML] The role of selenium in type-2 diabetes mellitus and its metabolic comorbidities

H Steinbrenner, LH Duntas, MP Rayman - Redox biology, 2022 - Elsevier
This review addresses the role of the essential trace element, selenium, in type-2 diabetes
mellitus (T2DM) and its metabolic co-morbidities, ie, metabolic syndrome, obesity and non …