Liver X receptors: regulators of cholesterol metabolism, inflammation, autoimmunity, and cancer

MT Bilotta, S Petillo, A Santoni, M Cippitelli - Frontiers in immunology, 2020 - frontiersin.org
The interplay between cellular stress and immune response can be variable and sometimes
contradictory. The mechanisms by which stress-activated pathways regulate the …

Comorbidity in multiple sclerosis: implications for patient care

RA Marrie - Nature Reviews Neurology, 2017 - nature.com
Most efforts aimed at understanding the notable heterogeneity of outcomes in multiple
sclerosis (MS) have focused on disease-specific factors, such as symptoms at initial …

The potential therapeutic effect of statins in multiple sclerosis: beneficial or detrimental effects

HM Al-Kuraishy, AI Al-Gareeb, HM Saad… - …, 2023 - Springer
Multiple sclerosis (MS) is a chronic progressive disabling disease of the central nervous
system (CNS) characterized by demyelination and neuronal injury. Dyslipidemia is observed …

The physiology of foamy phagocytes in multiple sclerosis

E Grajchen, JJA Hendriks, JFJ Bogie - Acta neuropathologica …, 2018 - Springer
Multiple sclerosis (MS) is a chronic disease of the central nervous system characterized by
massive infiltration of immune cells, demyelination, and axonal loss. Active MS lesions …

Identifying progression in multiple sclerosis: new perspectives

M Filippi, P Preziosa, D Langdon… - Annals of …, 2020 - Wiley Online Library
The identification of progression in multiple sclerosis is typically retrospective. Given the
profound burden of progressive multiple sclerosis, and the recent development of effective …

Dietary cholesterol promotes repair of demyelinated lesions in the adult brain

SA Berghoff, N Gerndt, J Winchenbach… - Nature …, 2017 - nature.com
Multiple Sclerosis (MS) is an inflammatory demyelinating disorder in which remyelination
failure contributes to persistent disability. Cholesterol is rate-limiting for myelin biogenesis in …

Obesity worsens central inflammation and disability in multiple sclerosis

M Stampanoni Bassi, E Iezzi, F Buttari… - Multiple Sclerosis …, 2020 - journals.sagepub.com
Background: Previous studies evidenced a link between metabolic dysregulation,
inflammation, and neurodegeneration in multiple sclerosis (MS). Objectives: To explore …

Multiple sclerosis and obesity: The role of adipokines

J Correale, M Marrodan - Frontiers in immunology, 2022 - frontiersin.org
Multiple Sclerosis (MS), a chronic inflammatory disease of the central nervous system that
leads to demyelination and neurodegeneration has been associated with various …

Prevalence of comorbidities, overweight and obesity in an international sample of people with multiple sclerosis and associations with modifiable lifestyle factors

CH Marck, SL Neate, KL Taylor, TJ Weiland… - PloS one, 2016 - journals.plos.org
Multiple sclerosis (MS) is a chronic neurological disorder, often affecting young people.
Comorbid disorders such as depression, anxiety and hypertension are common and can …

Randomized-controlled trial of a modified Mediterranean dietary program for multiple sclerosis: a pilot study

IK Sand, EKT Benn, M Fabian, KC Fitzgerald… - Multiple sclerosis and …, 2019 - Elsevier
Background There is a high level of interest in the potential role of diet among the MS
community. There is a limited level of evidence for a Mediterranean-style dietary pattern in …