Abstract Background Chondroitin sulfate proteoglycans (CSPGs) are principal pericellular
and extracellular components that form regulatory milieu involving numerous biological and …

Following CNS injury, in an apparently counterintuitive response, scar tissue formation
inhibits axonal growth, imposing a major barrier to regeneration. Accordingly, scar …

Research of the past 25 years has shown that astrocytes do more than participating and
building up the blood-brain barrier and detoxify the active synapse by reuptake of …

Just as the epigenome, the proteome and the electrophysiological properties of a cell
influence its function, so too do its intrinsic mechanical properties and its extrinsic …

Glycosaminoglycans (GAGs) are an important component of the extracellular matrix as they
influence cell behavior and have been sought for tissue regeneration, biomaterials, and …

Abstract Chondroitin Sulfate Proteoglycans (CSPGs) are a major component of the
extracellular matrix in the central nervous system (CNS) and play critical role in the …

Glycosaminoglycans (GAGs) are complex polysaccharides, which play important roles in
cell growth, differentiation, morphogenesis, cell migration, and bacterial/viral infections …

In the central nervous system (CNS) chondroitin sulfate proteoglycans, as one of the major
barrier-forming molecules, influence cell migration patterns and axon pathfinding. By …

The extracellular matrix (ECM) of the central nervous system is well recognized as a
migration and diffusion barrier that allows for the trapping and presentation of growth factors …

Glycosaminoglycans are unbranched polysaccharides composed of repeating units of
alternating uronic acids and amino sugars. Most glycosaminoglycans are covalently …