The gene ontology knowledgebase in 2023
Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …
comprehensive resource concerning the functions of genes and gene products (proteins …
Trends in the approval of cancer therapies by the FDA in the twenty-first century
EC Scott, AC Baines, Y Gong, R Moore Jr… - Nature Reviews Drug …, 2023 - nature.com
The cancer treatment landscape has changed dramatically since the turn of the century,
resulting in substantial improvements in outcomes for patients. This Review summarizes …
resulting in substantial improvements in outcomes for patients. This Review summarizes …
[HTML][HTML] Functional unknomics: Systematic screening of conserved genes of unknown function
JJ Rocha, SA Jayaram, TJ Stevens, N Muschalik… - PLoS …, 2023 - journals.plos.org
The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …
has become clear that scientific research tends to focus on well-studied proteins, leading to …
[HTML][HTML] Droplet-based single-cell joint profiling of histone modifications and transcriptomes
Abstract We previously reported Paired-Tag, a combinatorial indexing-based method that
can simultaneously map histone modifications and gene expression at single-cell resolution …
can simultaneously map histone modifications and gene expression at single-cell resolution …
[PDF][PDF] Engineering RNA export for measurement and manipulation of living cells
A system for programmable export of RNA molecules from living cells would enable both
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …
The hagfish genome and the evolution of vertebrates
F Marlétaz, N Timoshevskaya, VA Timoshevskiy… - Nature, 2024 - nature.com
As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a critical
window into early vertebrate evolution1–3. Here, we investigate the complex history, timing …
window into early vertebrate evolution1–3. Here, we investigate the complex history, timing …
[HTML][HTML] Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer
V Cigliola, A Shoffner, N Lee, J Ou, TJ Gonzalez… - Nature …, 2023 - nature.com
Unlike adult mammals, zebrafish regenerate spinal cord tissue and recover locomotor ability
after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords …
after a paralyzing injury. Here, we find that ependymal cells in zebrafish spinal cords …
[HTML][HTML] The Gene Ontology knowledgebase in 2023
Abstract The Gene Ontology (GO) knowledgebase (http://geneontology. org) is a
comprehensive resource concerning the functions of genes and gene products (proteins …
comprehensive resource concerning the functions of genes and gene products (proteins …
[HTML][HTML] Identification of constrained sequence elements across 239 primate genomes
Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …
in modern day biology by providing a great depth of information, with its application to …