Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

Introduction Lipidomics focuses on the in-depth analysis of lipids, which are crucial
macromolecules involved in a wide range of metabolic pathways. The increased …

Prostate cancer (PCa) metabolism appears to be unique in comparison with other types of
solid cancers. Normal prostate cells mainly rely on glucose oxidation to provide precursors …

Obesity is associated with a range of health outcomes that are of clinical and public health
significance, including cancer. Herein, we summarize epidemiologic and preclinical …

Hepatocellular carcinoma (HCC) is characterized by a poor prognosis and is one of the
leading causes of cancer-related death worldwide. Simvastatin, an HMG-CoA reductase …

In a variety of normal and pathological cell types, Rho-kinases I and II (ROCKI/II) play a
pivotal role in the organization of the nonmuscle and smooth muscle cytoskeleton and …

Renal cell carcinoma (RCC) is the most lethal type of genitourinary cancer due to its occult
onset and resistance to chemotherapy and radiation. Recently, accumulating evidence has …

Mevalonate (MVA) is synthesized from 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)
by HMG-CoA reductase (HMG-CoAR). MVA is further metabolized to farnesyl …

The role of lipid metabolism has gained particular interest in prostate cancer research. A
large body of literature has outlined the unique upregulation of de novo lipid synthesis in …

Obesity has been closely related to cancer progression, recurrence, metastasis, and
treatment resistance. We aim to review recent progress in the knowledge on the obese …