Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Of the many pathogens that infect humans and animals, a large number use cells of the host
organism as protected sites for replication. To reach the relevant intracellular compartments …

Multivalency plays a major role in biological processes and particularly in the relationship
between pathogenic microorganisms and their host that involves protein–glycan recognition …

The function of deciphering the biological information encoded by the glycome, which is the
entire repertoire of complex sugar structures expressed by cells and tissues, is assigned in …

Galectins are a group of evolutionarily conserved proteins with the ability to bind β‐
galactosides through characteristic carbohydrate‐recognition domains (CRD). Galectin‐3 is …

The compartmentalization of eukaryotic cells, which is essential for their viability and
functions, is ensured by single or double bilayer membranes that separate the cell from the …

Major histocompatibility complex (MHC) class I and II are glycoproteins that can present
antigenic peptides at the cell surface for recognition and activation of circulating T …

Early studies have revealed that some mammalian plasma membrane proteins exist in small
nanoclusters. The advent of super-resolution microscopy has corroborated and extended …

The β-galactoside-binding protein galectin-9 is critical in regulating the immune response,
but the mechanism by which it functions remains unclear. We have demonstrated that …

Galectins are among the most widely expressed class of lectins in all organisms. They
typically bind β-galactose-containing glycoconjugates and share primary structural …