[HTML][HTML] The Keap1-Nrf2 system: a mediator between oxidative stress and aging

C Yu, JH Xiao - Oxidative Medicine and Cellular Longevity, 2021 - hindawi.com
Oxidative stress, a term that describes the imbalance between oxidants and antioxidants,
leads to the disruption of redox signals and causes molecular damage. Increased oxidative …

Recent aspects of the effects of zinc on human health

CT Chasapis, PSA Ntoupa, CA Spiliopoulou… - Archives of …, 2020 - Springer
Zinc (Zn) is one of the most important essential nutrients of great public health significance. It
is involved in numerous biological functions and it is considered as a multipurpose trace …

[HTML][HTML] Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

A Więckowska-Gacek, A Mietelska-Porowska… - Ageing research …, 2021 - Elsevier
An excess of saturated fatty acids and simple sugars in the diet is a known environmental
risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes …

[HTML][HTML] Involvement of lipids in Alzheimer's disease pathology and potential therapies

H Chew, VA Solomon, AN Fonteh - Frontiers in physiology, 2020 - frontiersin.org
Lipids constitute the bulk of the dry mass of the brain and have been associated with healthy
function as well as the most common pathological conditions of the brain. Demographic …

Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases

TS Agidigbi, C Kim - International journal of molecular sciences, 2019 - mdpi.com
Reactive oxygen species (ROS) and free radicals are essential for transmission of cell
signals and other physiological functions. However, excessive amounts of ROS can cause …

[HTML][HTML] Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: The role of antioxidants in prevention and …

G Juszczyk, J Mikulska, K Kasperek, D Pietrzak… - Antioxidants, 2021 - mdpi.com
There is a growing body of scientific research showing the link between depression and
dementia in Alzheimer's disease (AD). The chronic stress contributes to the formation of …

Copper dyshomeostasis in neurodegenerative diseases—therapeutic implications

G Gromadzka, B Tarnacka, A Flaga… - International journal of …, 2020 - mdpi.com
Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

[HTML][HTML] Traditional uses, bioactive chemical constituents, and pharmacological and toxicological activities of Glycyrrhiza glabra L.(Fabaceae)

GES Batiha, AM Beshbishy, A El-Mleeh… - …, 2020 - ncbi.nlm.nih.gov
Traditional herbal remedies have been attracting attention as prospective alternative
resources of therapy for diverse diseases across many nations. In recent decades, medicinal …

[HTML][HTML] Neuroprotection against oxidative stress: Phytochemicals targeting TrkB signaling and the Nrf2-ARE antioxidant system

MA Hannan, R Dash, AAM Sohag… - Frontiers in Molecular …, 2020 - frontiersin.org
Oxidative stress (OS) plays a critical role in the pathophysiology of several brain-related
disorders, including neurodegenerative diseases and ischemic stroke, which are the major …

Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza glabra L. (Fabaceae)

G El-Saber Batiha, A Magdy Beshbishy, A El-Mleeh… - Biomolecules, 2020 - mdpi.com
Traditional herbal remedies have been attracting attention as prospective alternative
resources of therapy for diverse diseases across many nations. In recent decades, medicinal …