Immunotherapeutic progress and application of bispecific antibody in cancer
J Kang, T Sun, Y Zhang - Frontiers in Immunology, 2022 - frontiersin.org
Bispecific antibodies (bsAbs) are artificial antibodies with two distinct antigen-binding sites
that can bind to different antigens or different epitopes on the same antigen. Based on a …
that can bind to different antigens or different epitopes on the same antigen. Based on a …
Simultaneous crosslinking of CD20 and CD38 receptors by drug-free macromolecular therapeutics enhances B cell apoptosis in vitro and in vivo
MT Gambles, J Li, DC Radford, D Sborov… - Journal of Controlled …, 2022 - Elsevier
Abstract Drug-Free Macromolecular Therapeutics (DFMT) is a new paradigm in
macromolecular therapeutics that induces apoptosis in target cells by crosslinking receptors …
macromolecular therapeutics that induces apoptosis in target cells by crosslinking receptors …
Facilitating high throughput bispecific antibody production and potential applications within biopharmaceutical discovery workflows
C Fawcett, JR Tickle, CH Coles - Mabs, 2024 - Taylor & Francis
ABSTRACT A major driver for the recent investment surge in bispecific antibody (bsAb)
platforms and products is the multitude of distinct mechanisms of action that bsAbs offer …
platforms and products is the multitude of distinct mechanisms of action that bsAbs offer …
SpyMask enables combinatorial assembly of bispecific binders
CL Driscoll, AH Keeble, MR Howarth - Nature Communications, 2024 - nature.com
Bispecific antibodies are a successful and expanding therapeutic class. Standard
approaches to generate bispecifics are complicated by the need for disulfide …
approaches to generate bispecifics are complicated by the need for disulfide …
An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics
N Furtmann, M Schneider, N Spindler, B Steinmann… - MAbs, 2021 - Taylor & Francis
Next-generation multi-specific antibody therapeutics (MSATs) are engineered to combine
several functional activities into one molecule to provide higher efficacy compared to …
several functional activities into one molecule to provide higher efficacy compared to …
A Generic Approach for Miniaturized Unbiased High-Throughput Screens of Bispecific Antibodies and Biparatopic Antibody–Drug Conjugates
N Barron, S Dickgiesser, M Fleischer… - International Journal of …, 2024 - mdpi.com
The toolbox of modern antibody engineering allows the design of versatile novel
functionalities exceeding nature's repertoire. Many bispecific antibodies comprise …
functionalities exceeding nature's repertoire. Many bispecific antibodies comprise …
Kinetics study of the natural split Npu DnaE intein in the generation of bispecific IgG antibodies
H Zong, L Han, J Chen, Z Pan, L Wang, R Sun… - Applied Microbiology …, 2022 - Springer
Rapid and efficient bispecific antibody (BsAb) production for industrial applications is still
facing many challenges. We reported a technology platform for generating bispecific IgG …
facing many challenges. We reported a technology platform for generating bispecific IgG …
A multivalent antibody assembled from different building blocks using tag/catcher systems: a case study
C Schindler, C Faust, H Sjuts, C Lange… - Protein Engineering …, 2022 - academic.oup.com
The field of therapeutic antibodies and, especially bi-or multispecific antibodies, is growing
rapidly. Especially for treating cancers, multispecific antibodies are very promising, as there …
rapidly. Especially for treating cancers, multispecific antibodies are very promising, as there …
[PDF][PDF] Application of Quality by Design (QbD) in the Development of Dry Powder Inhalers··········
ZH DONG, WU WZ - cjph.com.cn
Untitled Page 1 Page 2 月刊 1970 年 11 月创刊 第 52 卷第 2 期 2021 年 2 月 10 日出版 目 次
·专论与综述(Perspectives & Review)· 质量源于设计(QbD)在干粉吸入剂开发中的应用·································董子豪 …
·专论与综述(Perspectives & Review)· 质量源于设计(QbD)在干粉吸入剂开发中的应用·································董子豪 …