The mitochondrial and endoplasmic reticulum (ER) homeostasis is pivotal to the
maintenance of an array of physiological processes. The physical contact and association …

Mitophagy serves as a cardinal regulator in the maintenance of mitochondrial integrity,
function, and cardiovascular homeostasis, through the fine control and governance of …

Mitochondria are the principal sites of energy metabolism and provide most of the energy
needed for normal cellular function. They are dynamic organelles that constantly undergo …

Obesity-related non-alcoholic fatty liver disease (NAFLD) is connected with mitochondrial
stress and hepatocyte apoptosis. Parkin-related mitophagy sustains mitochondrial …

Ripk3-mediated cellular apoptosis is a major contributor to the pathogenesis of myocardial
ischemia reperfusion (IR) injury. However, the mechanisms by which Ripk3 influences …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …

Purpose Myocardial ischemic reperfusion injury (MIRI) is a crucial clinical problem globally.
The molecular mechanisms of MIRI need to be fully explored to develop new therapeutic …

Melatonin is a pleiotropic, indole secreted, and synthesized by the human pineal gland.
Melatonin has biological effects including anti-apoptosis, protecting mitochondria, anti …

Abstract Latent membrane protein 1 (LMP1) is a major Epstein–Barr virus (EBV)-encoded
oncoprotein involved in latency infection that regulates mitochondrial functions to facilitate …

Sex differences in diseases involving oxidative and proteolytic stress are common, including
greater ischemic heart disease, Parkinson disease and stroke in men, and greater …