The mitochondrial unfolded protein response (UPR mt) is an adaptive transcriptional
response involving the activation of proteases, chaperones, and antioxidant enzymes and …

Background The regulation of microglial function via mitochondrial homeostasis is important
in the development of neuroinflammation. The underlying mechanism for this regulatory …

Worldwide morbidity and mortality from acute myocardial infarction (AMI) and related heart
failure remain high. While effective early reperfusion of the criminal coronary artery after a …

The heart is a highly energy-dependent organ, and most of its energy is provided by
mitochondrial oxidative phosphorylation. Therefore, maintaining a well-functioning …

Background/Aims: The Hippo-Yap pathway is associated with tumor development and
progression. However, little evidence is available concerning its role in cancer cell apoptosis …

Coronary microvascular dysfunction (CMD) refers to a subset of structural and/or functional
disorders of coronary microcirculation that lead to impaired coronary blood flow and …

Cerebral ischemia-reperfusion injury (IRI) potentiates existing brain damage and increases
mortality and morbidity via poorly understood mechanisms. The aim of our study is to …

The extensive application of silica nanoparticles (SiNPs) brings about inevitable
occupational, environmental, and even iatrogenic exposure for human beings. The liver …

Mitochondria, the intracellular organelles for cellular aerobic respiration and energy
production, play an important role in the regulation of cell metabolism and cell fate …

Mitochondrial dysfunction has been acknowledged as the key pathogenic mechanism in
cerebral ischemia–reperfusion (IR) injury. Mitophagy is the protective system used to sustain …