[HTML][HTML] Clinical effects of Lewy body pathology in cognitively impaired individuals

C Quadalti, S Palmqvist, S Hall, M Rossi… - Nature Medicine, 2023 - nature.com
There is poor knowledge about the clinical effects of Lewy body (LB) pathology in patients
with cognitive impairment, especially when coexisting with Alzheimer's disease (AD) …

[HTML][HTML] Fluid and biopsy based biomarkers in Parkinson's disease

DG Coughlin, DJ Irwin - Neurotherapeutics, 2023 - Elsevier
Several advances in fluid and tissue-based biomarkers for use in Parkinson's disease (PD)
and other synucleinopathies have been made in the last several years. While work …

European intersocietal recommendations for the biomarker-based diagnosis of neurocognitive disorders

GB Frisoni, C Festari, F Massa, MC Ramusino… - The Lancet …, 2024 - thelancet.com
The recent commercialisation of the first disease-modifying drugs for Alzheimer's disease
emphasises the need for consensus recommendations on the rational use of biomarkers to …

[HTML][HTML] Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers

LL Gibson, C Abdelnour, J Chong… - Current Opinion in …, 2023 - journals.lww.com
Clinical trials in dementia with Lewy bodies: the evolving c... : Current Opinion in Neurology
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient …

Morphological characteristics differentiate dementia with Lewy bodies from Parkinson disease with and without dementia

KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Dementia with Lewy bodies (DLB) and Parkinson disease (PD) with and without dementia
are entities of a spectrum of Lewy body diseases. About 26.3% of all PD patients develop …

Research diagnostic criteria for mild cognitive impairment with Lewy bodies: A systematic review and meta‐analysis

PC Donaghy, C Carrarini, D Ferreira… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Operationalized research criteria for mild cognitive impairment with Lewy
bodies (MCI‐LB) were published in 2020. The aim of this systematic review and meta …

Practical use of DAT SPECT imaging in diagnosing dementia with Lewy bodies: a US perspective of current guidelines and future directions

DM O'Shea, A Arkhipenko, D Galasko… - Frontiers in …, 2024 - frontiersin.org
Background Diagnosing Dementia with Lewy Bodies (DLB) remains a challenge in clinical
practice. The use of 123I-ioflupane (DaTscan™) SPECT imaging, which detects reduced …

Pathobiology of Cognitive Impairment in Parkinson Disease: Challenges and Outlooks

KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …

[HTML][HTML] A precision medicine approach to dementia care: Syndrome, etiology, and copathology

DL Fischer, WW Seeley - Practical neurology (Fort Washington, Pa …, 2023 - ncbi.nlm.nih.gov
Recognizing multiple neuropathological entities in people with dementia improves
understanding of diagnosis, prognosis, and expected outcomes from therapies. Care for the …

[HTML][HTML] In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use

JI López-Carbonero, I García-Toledo… - Translational …, 2024 - Springer
TDP-43 proteinopathies are a heterogeneous group of neurodegenerative disorders that
share the presence of aberrant, misfolded and mislocalized deposits of the protein TDP-43 …