Rational design and synthesis of novel quinazolinone N-acetohydrazides as type II multi-kinase inhibitors and potential anticancer agents

SS Abd El-Karim, YM Syam, AM El Kerdawy… - Bioorganic …, 2024 - Elsevier
In the current investigation, a new class of quinazolinone N-acetohydrazides 9a-v was
designed as type II multi-kinase inhibitors. The target quinazolinones were tailored so that …

[HTML][HTML] Design, Synthesis, and Antifungal Activity of Some Novel Phenylthiazole Derivatives Containing an Acylhydrazone Moiety

Y Tian, J Shi, X Deng, T Yu, Y Hu, R Hu, Y Lei, L Yu… - Molecules, 2023 - mdpi.com
Crop fungal diseases pose a serious threat to global crop production and quality.
Developing new and efficient fungicides is an important measure to control crop diseases …

Novel N‐pyrocatechoyl and N‐pyrogalloyl hydrazone antioxidants endowed with cytotoxic and antibacterial activity

J Branković, V Matejić, D Simijonović… - Archiv der …, 2024 - Wiley Online Library
Over the years, pharmacological agents bearing antioxidant merits arose as beneficial in the
prophylaxis and treatment of various health conditions. Hazardous effects of radical species …

Development of Novel Indazolyl‐Acyl Hydrazones as Antioxidant and Anticancer Agents that Target VEGFR‐2 in Human Breast Cancer Cells

SM Parameshwaraiah, R Shivakumar… - Chemistry & …, 2024 - Wiley Online Library
The increased expression of VEGFR‐2 in a variety of cancer cells promotes a cascade of
cellular responses that improve cell survival, growth, and proliferation. Heterocycles are …

An allosteric inhibitor of the PhoQ histidine kinase with therapeutic potential against Salmonella infection

CA Lobertti, I Cabezudo, FO Gizzi… - Journal of …, 2024 - academic.oup.com
Background The upsurge of antimicrobial resistance demands innovative strategies to fight
bacterial infections. With traditional antibiotics becoming less effective, anti-virulence agents …