Vestibular schwannoma (VS) is a benign tumor that originates from Schwann cells in the
vestibular component. Surgical treatment for VS has gradually declined over the past few …

The transcriptional regulators YAP and TAZ are involved in numerous physiological
processes including organ development, growth, immunity and tissue regeneration. YAP …

Schwannoma tumours typically arise on the eighth cranial nerve and are mostly caused by
loss of the tumour suppressor Merlin (NF2). There are no approved chemotherapies for …

Hippo pathway is an evolutionarily conserved signaling pathway comprising a series of
MST/LATS kinase complexes. Its key transcriptional coactivators YAP and TAZ regulate …

Cancer can be considered as a communication disease between and within cells;
nevertheless, there is no effective therapy for the condition, and this disease is typically …

Initially identified in Drosophila, the Hippo signaling pathway regulates how cells respond to
their environment by controlling proliferation, migration and differentiation. Many recent …

Dear Editor, Schwannomas are peripheral nervous system tumors that cause chronic pain,
numbness, and potentially lifethreatening organ dysfunction. Surgery is a conventional …

Recent reports suggest a link between positive regulation of the Hippo pathway with bipolar
disorder (BD), and the Hippo pathway is known to interact with multiple other signaling …

The understanding of schwannoma tumorigenesis has been reshaped by the recent
identification of SH3PXD2A:: HTRA1 fusion in 10% of intracranial/spinal schwannomas …

Abstract The Ras–Erk pathway is frequently overactivated in human tumors.
Neurofibromatosis types 1 and 2 (NF1, NF2) are characterized by multiple tumors of …