Blood pressure is determined by cardiac output and systemic vascular resistance, and
mediators that induce vasoconstriction will increase systemic vascular resistance and thus …

Pulmonary hypertension has high disability and mortality rates. Among them, pulmonary
hypertension caused by left heart disease (PH-LHD) is the most common type. According to …

Unlike in the Cnidaria, where muscle cells are coupled together into an epithelium,
ctenophore muscles are single, elongated, intramesogleal structures resembling vertebrate …

The pharmacology of calcium-activated chloride current is not well developed. Peptides from
scorpion venom present potent pharmacological actions on ionic conductance used to …

Vasomotion is the oscillation of vascular tone which gives rise to flow motion of blood into an
organ. As is well known, spontaneous contractile organs such as heart, GI, and …

In brief Inappropriate uterine contractions are a matter of concern during pregnancy or
menses. We identified the transient receptor potential melastatin 4 (TRPM4) ion channel as …

Objective Delayed cerebral ischemia (DCI)-induced cerebral infarction is a major cause of
adverse neurological outcomes following aneurysmal subarachnoid hemorrhage (aSAH) …

Background: Panx1 (pannexin 1) forms high conductance channels that secrete ATP upon
stimulation. The role of Panx1 in mediating constriction in response to direct sympathetic …

Cl− influx and efflux through Cl− channels play a role in regulating the homeostasis of
biological functions. Therefore, the hyperfunction or dysfunction of Cl− channels elicits …

Background Abnormal cystic fibrosis transmembrane conductance regulator (CFTR) function
in cystic fibrosis (CF) has been linked to airway smooth muscle abnormalities including …