The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …

Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system which is characterized by demyelinating lesions and axonal damage. MS is a …

Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …

Kappa free light chain (KFLC) index, a measure for intrathecal production of free kappa
chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis …

The clinical course of multiple sclerosis (MS) is highly variable among patients, thus creating
important challenges for the neurologist to appropriately treat and monitor patient progress …

Objective To determine the best method to measure intrathecal immunoglobulin (Ig) M
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …

While complement-dependent cytotoxicity (CDC) is a known effector mechanism in
aquaporin-4-immunoglobulin (Ig) G-positive (AQP4-IgG+) neuromyelitis optica spectrum …

Objective Intrathecal Immunoglobulin M synthesis (IgMIntrathecal Fraction (IF)+) and spinal
MRI lesions are both strong independent predictors of higher disease activity and severity in …

Multiple sclerosis (MS) patients with immunoglobulin gamma (IgG) oligoclonal bands (OCB)
in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features …

Patients with multiple sclerosis (MS) suffer with age an early immunosenescence process,
which influence the treatment response and increase the risk of infections. We explored …