Role of B cells in multiple sclerosis and related disorders
G Comi, A Bar‐Or, H Lassmann, A Uccelli… - Annals of …, 2021 - Wiley Online Library
The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …
[HTML][HTML] The translatability of multiple sclerosis animal models for biomarkers discovery and their clinical use
D Birmpili, I Charmarke Askar, K Bigaut… - International journal of …, 2022 - mdpi.com
Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous
system which is characterized by demyelinating lesions and axonal damage. MS is a …
system which is characterized by demyelinating lesions and axonal damage. MS is a …
Limited proteolysis–mass spectrometry reveals aging-associated changes in cerebrospinal fluid protein abundances and structures
Cerebrospinal fluid (CSF) proteins and their structures have been implicated in aging and
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …
neurodegenerative diseases. In the present study, we used limited proteolysis–mass …
Kappa free light chain index as a diagnostic biomarker in multiple sclerosis: a real‐world investigation
I Rosenstein, S Rasch, M Axelsson… - Journal of …, 2021 - Wiley Online Library
Kappa free light chain (KFLC) index, a measure for intrathecal production of free kappa
chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis …
chains, has been increasingly recognized for its diagnostic potential in multiple sclerosis …
[HTML][HTML] Using personalized prognosis in the treatment of relapsing multiple sclerosis: a practical guide
B Van Wijmeersch, HP Hartung, P Vermersch… - Frontiers in …, 2022 - frontiersin.org
The clinical course of multiple sclerosis (MS) is highly variable among patients, thus creating
important challenges for the neurologist to appropriately treat and monitor patient progress …
important challenges for the neurologist to appropriately treat and monitor patient progress …
Predicting aggressive multiple sclerosis with intrathecal IgM synthesis among patients with a clinically isolated syndrome
E Monreal, S Sainz de la Maza… - Neurology …, 2021 - AAN Enterprises
Objective To determine the best method to measure intrathecal immunoglobulin (Ig) M
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …
synthesis (ITMS), a biomarker of worse prognosis in multiple sclerosis (MS). We compared …
C3 and C4 complement levels in AQP4-IgG-positive NMOSD and in MOGAD
F Pache, M Ringelstein, O Aktas, I Kleiter… - Journal of …, 2021 - Elsevier
While complement-dependent cytotoxicity (CDC) is a known effector mechanism in
aquaporin-4-immunoglobulin (Ig) G-positive (AQP4-IgG+) neuromyelitis optica spectrum …
aquaporin-4-immunoglobulin (Ig) G-positive (AQP4-IgG+) neuromyelitis optica spectrum …
Intrathecal IgM synthesis is associated with spinal cord manifestation and neuronal injury in early MS
J Oechtering, T Lincke, S Schaedelin… - Annals of …, 2022 - Wiley Online Library
Objective Intrathecal Immunoglobulin M synthesis (IgMIntrathecal Fraction (IF)+) and spinal
MRI lesions are both strong independent predictors of higher disease activity and severity in …
MRI lesions are both strong independent predictors of higher disease activity and severity in …
[HTML][HTML] Cerebrospinal fluid oligoclonal immunoglobulin gamma bands and long-term disability progression in multiple sclerosis: a retrospective cohort study
VD Karrenbauer, SK Bedri, J Hillert… - Scientific Reports, 2021 - nature.com
Multiple sclerosis (MS) patients with immunoglobulin gamma (IgG) oligoclonal bands (OCB)
in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features …
in the cerebrospinal fluid (CSF) have different genetic backgrounds and brain MRI features …
[HTML][HTML] Identification of the immunological changes appearing in the CSF during the early immunosenescence process occurring in multiple sclerosis
C Picón, A Tejeda-Velarde… - Frontiers in …, 2021 - frontiersin.org
Patients with multiple sclerosis (MS) suffer with age an early immunosenescence process,
which influence the treatment response and increase the risk of infections. We explored …
which influence the treatment response and increase the risk of infections. We explored …