Background Multiple sclerosis (MS) is an immune-mediated central nervous system (CNS)
inflammatory demyelinating disease in which analysis of clinical presentation, imaging …

Eighty-five percent of multiple sclerosis cases begin with a discrete attack termed clinically
isolated syndrome, but 37% of clinically isolated syndrome patients do not experience a …

Intrathecal IgM production in multiple sclerosis is associated with a worse disease course.
To investigate pathogenic relevance of autoreactive IgM in multiple sclerosis, CSF from two …

Background and Objectives Histopathologic studies have identified immunoglobulin (Ig)
deposition and complement activation as contributors of CNS tissue damage in multiple …

Background Reports on typical routine cerebrospinal fluid (CSF) findings are outdated
owing to novel reference limits (RL) and revised diagnostic criteria of Multiple Sclerosis …

Simple Summary Multiple sclerosis (MS) is a chronic, inflammatory disease that affects the
central nervous system, and is the most common cause of non-traumatic neurological …

Fluid phase biomarkers in multiple sclerosis : Current Opinion in Neurology Fluid phase
biomarkers in multiple sclerosis : Current Opinion in Neurology Log in or Register Subscribe to …

Clonally related B cells infiltrate the brain, meninges, and cerebrospinal fluid of MS patients,
but the mechanisms driving the B‐cell response and shaping the immunoglobulin …

Background Emerging evidence supports that determination of intrathecal immunoglobulin
M (IgM) synthesis (ITMS) and neurofilament light (NfL) concentration in cerebrospinal fluid …

The presence of intrathecal IgM synthesis (ITMS) has been associated with an aggressive
multiple sclerosis (MS) clinical course. In the present systematic review, we aimed at …