Abstract Cyclin-dependent kinase 4 (CDK4) and CDK6 are critical mediators of cellular
transition into S phase and are important for the initiation, growth and survival of many …

Proteolysis-targeting chimeras (PROTACs) are engineered techniques for targeted protein
degradation. A bifunctional PROTAC molecule with two covalently-linked ligands recruits …

Aberrancy in cell cycle progression is one of the fundamental mechanisms underlying
tumorigenesis, making regulators of the cell cycle machinery rational anticancer therapeutic …

The cyclin-dependent kinase (CDK) 4/6 inhibitors belong to a new class of drugs that
interrupt proliferation of malignant cells by inhibiting progression through the cell cycle …

Cellular senescence is an essential tumor suppressive mechanism that prevents the
propagation of oncogenically activated, genetically unstable, and/or damaged cells …

Tumor suppressor genes cooperate with each other in tumors. Three important tumor
suppressor proteins, retinoblastoma (Rb), p53, phosphatase, and tensin homolog deleted …

The integration of mass spectrometry-based proteomics with next-generation DNA and RNA
sequencing profiles tumors more comprehensively. Here this" proteogenomics" approach …

Abstract Aberrant N 6-methyladenosine (m6A) modification has emerged as a driver of
tumor initiation and progression, yet how long noncoding RNAs (lncRNA) are involved in the …

Progression through G1/S phase of the cell cycle is coordinated by cyclin-dependent kinase
(CDK) activities. Here, we find that the requirement for different CDK activities and cyclins in …

Genetic alterations affecting RAS proteins are commonly found in human cancers. Roughly
a fourth of melanoma patients carry activating NRAS mutations, rendering this malignancy …