Highlights•Membrane cofactor protein (MCP; CD46) protects host cells from complement
attack.•Rare variants leading to haploinsufficiency predispose to renal disease.•Subversion …

The complement system, an arm of the innate immune system plays a critical role in both
health and disease. The complement system is highly complex with dual possibilities …

Allergic asthma is a common chronic inflammatory disease characterized by airway
inflammation, mucus hypersecretion and airway remodeling. Autophagy is a highly …

Intestinal epithelial cells (IEC) are important parts of the mucosal barrier, whose function can
be impaired upon various injury factors such as lipopolysaccharide. Although food-derived …

Patients with chronic lung disease suffer from persistent inflammation and are typically
colonized by pro-inflammatory pathogenic bacteria. Besides these pathogens, a wide variety …

Autophagy is a major self-degradative process through which cytoplasmic material,
including damaged organelles and proteins, are delivered and degraded in the lysosome …

Introduction Abnormal gene expression patterns may contribute to the onset and
progression of late‐onset Alzheimer's disease (LOAD). Methods We performed …

Maintenance of homeostasis at body barriers that are constantly challenged by microbes,
toxins and potentially bioactive (macro) molecules requires complex, highly orchestrated …

The innate immune system-based recognition of the pathogens or their PAMPs initiates the
pro-inflammatory immune response required for the maintenance of the homeostasis. The …

Background Autophagy has been proven to play an important role in the pathogenesis of
asthma and the regulation of the airway epithelial immune microenvironment. However, a …