The anti-viral pattern recognition receptor STING and its partnering cytosolic DNA sensor
cGAS have been increasingly recognized to respond to self DNA in multiple pathologic …

DNA viruses are linked to many infectious diseases and contribute significantly to human
morbidity and mortality worldwide. Moreover, DNA viral infections are usually lifelong and …

Immune recognition of cytosolic DNA represents a central antiviral defence mechanism.
Within the host, short single-stranded DNA (ssDNA) continuously arises during the repair of …

DNA damage occurs throughout tumorigenesis and development. The immunogenicity of
DNA makes it an immune stimulatory molecule that initiates strong inflammatory responses …

Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-
associated molecular pattern in conditions such as autoimmunity, cancer, and trauma. We …

Innate immunity is the first line of host defense against invading pathogens. The detection of
aberrant nucleic acids which represent some conserved PAMPs triggers robust type I IFN …

Systemic inflammation is central to aging‐related conditions. However, the intrinsic factors
that induce inflammation are not well understood. We previously identified a cell …

Stimulator of interferon genes (STING), a major adaptor protein in antiviral innate immune
signaling, is considered as one of the most important regulators of antiviral and antitumor …

APOBEC3A is a cytidine deaminase driving mutagenesis in tumors. While APOBEC3A-
induced mutations are common, APOBEC3A expression is rarely detected in cancer cells …