[HTML][HTML] Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment
In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …
remarkable achievements. However, emerging evidence has shown that chemoresistance is …
The role of pyroptosis in cancer: pro-cancer or pro-“host”?
X Xia, X Wang, Z Cheng, W Qin, L Lei, J Jiang… - Cell death & …, 2019 - nature.com
Programmed cell death (PCD) refers to the way in which cells die depending on specific
genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all …
genes encoding signals or activities. Apoptosis, autophagy, and pyroptosis are all …
NLRP3 inflammasome—a key player in antiviral responses
C Zhao, W Zhao - Frontiers in immunology, 2020 - frontiersin.org
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …
development of an organism. Emerging evidence also indicates that cell death contributes to …
Emerging pyroptosis-engineered nanobiotechnologies regulate cancers and inflammatory diseases: A double-edged sword
Y Zhang, C Fang, W Zhang, K Zhang - Matter, 2022 - cell.com
Pyroptosis is closely associated with tumors and inflammatory diseases. By enhancing
pyroptosis, direct and immune-response-triggered deaths of tumor cells are increased …
pyroptosis, direct and immune-response-triggered deaths of tumor cells are increased …
Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis
SM Man - Nature reviews Gastroenterology & hepatology, 2018 - nature.com
Inflammasome signalling is an emerging pillar of innate immunity and has a central role in
the regulation of gastrointestinal health and disease. Activation of the inflammasome …
the regulation of gastrointestinal health and disease. Activation of the inflammasome …
[HTML][HTML] Essential role for autophagy in life span extension
F Madeo, A Zimmermann, MC Maiuri… - The Journal of clinical …, 2015 - Am Soc Clin Investig
Life and health span can be prolonged by calorie limitation or by pharmacologic agents that
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …
mimic the effects of caloric restriction. Both starvation and the genetic inactivation of nutrient …
Cell pyroptosis in health and inflammatory diseases
Y Wu, J Zhang, S Yu, Y Li, J Zhu, K Zhang… - Cell death …, 2022 - nature.com
Inflammation is a defense mechanism that can protect the host against microbe invasion. A
proper inflammatory response can maintain homeostasis, but continuous inflammation can …
proper inflammatory response can maintain homeostasis, but continuous inflammation can …
Cytosolic recognition of microbes and pathogens: inflammasomes in action
Infection is a dynamic biological process underpinned by a complex interplay between the
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …
pathogen and the host. Microbes from all domains of life, including bacteria, viruses, fungi …
Cadmium and molybdenum co-induce pyroptosis via ROS/PTEN/PI3K/AKT axis in duck renal tubular epithelial cells
C Zhang, T Lin, G Nie, R Hu, S Pi, Z Wei, C Wang… - Environmental …, 2021 - Elsevier
Cadmium (Cd) and excess molybdenum (Mo) are harmful to animals, but the combined
nephrotoxic mechanism of Cd and Mo in duck remains poorly elucidated. To assess joint …
nephrotoxic mechanism of Cd and Mo in duck remains poorly elucidated. To assess joint …