Repetitive elements in aging and neurodegeneration
KE Copley, J Shorter - Trends in Genetics, 2023 - cell.com
Repetitive elements (REs), such as transposable elements (TEs) and satellites, comprise
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
much of the genome. Here, we review how TEs and (peri) centromeric satellite DNA may …
The sound of silence: mechanisms and implications of HUSH complex function
M Seczynska, PJ Lehner - Trends in Genetics, 2023 - cell.com
The vertebrate genome is under constant threat of invasion by genetic parasites. Whether
the host can immediately recognize and respond to invading elements has been unclear …
the host can immediately recognize and respond to invading elements has been unclear …
Genomics of cold adaptations in the Antarctic notothenioid fish radiation
Numerous novel adaptations characterise the radiation of notothenioids, the dominant fish
group in the freezing seas of the Southern Ocean. To improve understanding of the …
group in the freezing seas of the Southern Ocean. To improve understanding of the …
[HTML][HTML] The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes
The mobility of transposable elements (TEs) contributes to evolution of genomes. Their
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …
uncontrolled activity causes genomic instability; therefore, expression of TEs is silenced by …
Transposable elements drive the evolution of metazoan zinc finger genes
JN Wells, NC Chang, J McCormick… - Genome …, 2023 - genome.cshlp.org
Cys2-His2 zinc finger genes (ZNFs) form the largest family of transcription factors in
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …
metazoans. ZNF evolution is highly dynamic and characterized by the rapid expansion and …
Retrotransposon-mediated evolutionary rewiring of a pathogen response orchestrates a resistance phenotype in an insect host
Z Guo, L Guo, Y Bai, S Kang, D Sun… - Proceedings of the …, 2023 - National Acad Sciences
Ongoing host–pathogen interactions can trigger a coevolutionary arms race, while genetic
diversity within the host can facilitate its adaptation to pathogens. Here, we used the …
diversity within the host can facilitate its adaptation to pathogens. Here, we used the …
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
Trimethylation of histone H3 lysine 9 (H3K9me3) is crucial for the regulation of gene
repression and heterochromatin formation, cell-fate determination and organismal …
repression and heterochromatin formation, cell-fate determination and organismal …
Take a walk on the KRAB side
O Rosspopoff, D Trono - Trends in Genetics, 2023 - cell.com
Canonical Krüppel-associated box (KRAB)-containing zinc finger proteins (KZFPs) act as
major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the …
major repressors of transposable elements (TEs) via the KRAB-mediated recruitment of the …
Co-transcriptional genome surveillance by HUSH is coupled to termination machinery
AL Spencley, S Bar, T Swigut, RA Flynn, CH Lee… - Molecular cell, 2023 - cell.com
The HUSH complex recognizes and silences foreign DNA such as viruses, transposons, and
transgenes without prior exposure to its targets. Here, we show that endogenous targets of …
transgenes without prior exposure to its targets. Here, we show that endogenous targets of …
Endogenous retroviruses in development and health
Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …
the viral genome became embedded as a dormant regulatory element within the host …