Pathophysiology and pathogenic mechanisms of pulmonary hypertension: role of membrane receptors, ion channels, and Ca2+ signaling

A Balistrieri, A Makino, JXJ Yuan - Physiological reviews, 2023 - journals.physiology.org
The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies

H Christou, RA Khalil - American Journal of Physiology …, 2022 - journals.physiology.org
Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …

Harmful impact of tobacco smoking and alcohol consumption on the atrial myocardium

AH Ohlrogge, L Frost, RB Schnabel - Cells, 2022 - mdpi.com
Tobacco smoking and alcohol consumption are widespread exposures that are legal and
socially accepted in many societies. Both have been widely recognized as important risk …

E-cigarette exposure with or without heating the e-liquid induces differential remodeling in the lungs and right heart of mice

Y Getiye, MR Peterson, BD Phillips, D Carrillo… - Journal of Molecular and …, 2022 - Elsevier
Various cardiopulmonary pathologies associated with electronic cigarette (EC) vaping have
been reported. This study investigated the differential adverse effects of heating-associated …

Alpha7 nicotinic acetylcholine receptor mediates chronic nicotine inhalation-induced cardiopulmonary dysfunction

AK Whitehead, ND Fried, Z Li, K Neelamegam… - Clinical …, 2022 - portlandpress.com
Cigarette smoking remains the leading modifiable risk factor for cardiopulmonary diseases;
however, the effects of nicotine alone on cardiopulmonary function remain largely unknown …

Cardiovascular consequences of vaping

O Echeagaray, C Savko, A Gallo… - Current opinion in …, 2022 - journals.lww.com
This review summarizes cardiovascular consequences of vaping from cumulative research
findings. Strategic application of emerging technologies to understand the impact of vaping …

Pathogenic mechanisms of pulmonary arterial hypertension: homeostasis imbalance of endothelium-derived relaxing and contracting factors

J Zhu, L Yang, Y Jia, A Balistrieri, DR Fraidenburg… - JACC: Asia, 2022 - jacc.org
Pulmonary arterial hypertension (PAH) is a progressive and fatal disease. Sustained
pulmonary vasoconstriction and concentric pulmonary vascular remodeling contribute to the …

Ovarian hormones do not mediate protection against pulmonary hypertension and right ventricular remodeling in female mice exposed to chronic, inhaled nicotine

ND Fried, A Whitehead, E Lazartigues… - American Journal …, 2022 - journals.physiology.org
Electronic cigarette use has increased globally prompting calls for improved understanding
of nicotine's cardiovascular health effects. Our group has previously demonstrated that …

[HTML][HTML] An integral perspective of canonical cigarette and e-cigarette-related cardiovascular toxicity based on the adverse outcome pathway framework

R Ding, X Ren, Q Sun, Z Sun, J Duan - Journal of Advanced Research, 2023 - Elsevier
Background Nowadays, cigarette smoking remains the leading cause of chronic disease
and premature death, especially cardiovascular disease. As an emerging tobacco product, e …

The efficacy and safety of Sacubitril/Valsartan on pulmonary hypertension in hemodialysis patients

C Zhao, Y Guo, Y Wang, L Wang, L Yu, Y Liang… - Frontiers in …, 2022 - frontiersin.org
Background Pulmonary hypertension (PH) is a common complication of end-stage renal
disease which is associated with adverse outcomes including all-cause mortality and …