The Role of Cardioprotection in Cancer Therapy Cardiotoxicity: JACC: CardioOncology State-of-the-Art Review

T Omland, SL Heck, G Gulati - Cardio Oncology, 2022 - jacc.org
Cardiotoxicity is a relatively frequent and potentially serious side effect of traditional and
targeted cancer therapies. Both general measures and specific pharmacologic …

Anthracycline-induced cardiotoxicity: causes, mechanisms, and prevention

A Bhagat, ES Kleinerman - … Clinical Perspectives: Past, Present and Future, 2020 - Springer
Doxorubicin is an anthracycline and one of the more effective chemotherapy agents used in
the treatment of children, adolescents, and adults with osteosarcoma. Despite its …

[HTML][HTML] Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations

G Curigliano, D Lenihan, M Fradley, S Ganatra… - Annals of …, 2020 - Elsevier
Cancer and cardiovascular (CV) disease are the most prevalent diseases in the developed
world. Evidence increasingly shows that these conditions are interlinked through common …

[HTML][HTML] Cardiotoxicity of anticancer drugs: Molecular mechanisms and strategies for cardioprotection

MB Morelli, C Bongiovanni, S Da Pra… - Frontiers in …, 2022 - frontiersin.org
Chemotherapy and targeted therapies have significantly improved the prognosis of
oncology patients. However, these antineoplastic treatments may also induce adverse …

Sodium-glucose co-transporter-2 inhibitors and cardiac outcomes among patients treated with anthracyclines

CA Gongora, ZD Drobni… - Heart Failure, 2022 - jacc.org
Background Sodium-glucose co-transporter-2 (SGLT2) inhibitors improve outcomes among
patients with established heart failure. Despite supportive basic science studies, there are …

[HTML][HTML] Strategies to prevent anthracycline-induced cardiotoxicity in cancer survivors

N Bansal, MJ Adams, S Ganatra, SD Colan… - Cardio-Oncology, 2019 - Springer
Cancer diagnostics and therapies have improved steadily over the last few decades,
markedly increasing life expectancy for patients at all ages. However, conventional and …

Inequity in cardio‐oncology: identifying disparities in cardiotoxicity and links to cardiac and cancer outcomes

RE Ohman, EH Yang, ML Abel - Journal of the American Heart …, 2021 - Am Heart Assoc
Minority and underresourced communities experience disproportionately high rates of fatal
cancer and cardiovascular disease. The intersection of these disparities within the …

Advances in Multimodality Imaging in Cardio-Oncology: JACC State-of-the-Art Review

LA Baldassarre, S Ganatra, J Lopez-Mattei… - Journal of the American …, 2022 - jacc.org
The population of patients with cancer is rapidly expanding, and the diagnosis and
monitoring of cardiovascular complications greatly rely on imaging. Numerous advances in …

[HTML][HTML] Mechanisms of anthracycline-induced cardiotoxicity: is mitochondrial dysfunction the answer?

A Murabito, E Hirsch, A Ghigo - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Cardiac side effects are a major drawback of anticancer therapies, often requiring the use of
low and less effective doses or even discontinuation of the drug. Among all the drugs known …

[HTML][HTML] Doxorubicin-induced acute cardiotoxicity is associated with increased oxidative stress, autophagy, and inflammation in a murine model

PL Dulf, M Mocan, CA Coadă, DV Dulf… - Naunyn-Schmiedeberg's …, 2023 - Springer
Drug-induced cardiotoxicity is a life-threatening side effect of doxorubicin (DOX) treatment
that impacts patient prognosis and survival. In the majority of cases, the acute clinical form …