Red blood cells (RBC) are the most abundant cell in the human body, with a central role in
oxygen transport and its delivery to tissues. However, omics technologies recently revealed …

Background: Blood transfusion is a life-saving intervention for millions of recipients
worldwide. Over the last 15 years, the advent of high-throughput, affordable omics …

Our aim is to present an updated overview of the erythrocyte metabolism highlighting its
richness and complexity. We have manually collected and connected the available …

Hemoglobin is the main protein of red blood cells that provides oxygen transport to all cells
of the human body. The ability of hemoglobin to bind the main low-molecular-weight thiol of …

Eukaryotic cells are defined as cells containing distinct nuclei and other membranous
organelles. However, red blood cells (RBCs) lack a nucleus and organelles—perhaps to …

An impressive effect of the infection with SARS-Co-19 is the impairment of oxygen uptake
due to lung injury. The reduced oxygen diffusion may potentially be counteracted by an …

Red blood cells (RBCs) are abundant (more than 80% of the total cells in the human body),
yet relatively simple, as they lack nuclei and organelles, including mitochondria. Since the …

Metabolic stress caused by a lack of glucose significantly affects the state of red blood cells,
where glycolysis is the main pathway for the production of ATP. Hypoglycemia can be both …

Oxidative phenomena are considered to lie at the root of the accelerated senescence
observed in red blood cells (RBCs) stored under standard blood bank conditions. It was …

Intracellular tripeptide glutathione is an important agent of cell survival under hypoxia.
Glutathione covalently binds to SH groups of hemoglobin cysteine residues, protecting them …