Electron–microscopic (EM) analysis preceded crystallographic analysis [1, 2] of Igs by over a
decade and was for a time the only direct way of analyzing their 3–D molecular structure …

We define multivalency to be the operation of multiple molecular recognition events of the
same kind occurring simultaneously between two entities (molecules, molecular aggregates …

Various native and hinge-modified forms of Ig with identical Ids were reacted with an anti-Id
mAb, and the resultant immune complexes were analyzed by negative stain immunoelectron …

We have employed the recently described crystallohydrodynamic approach to compare the
time-averaged domain orientation of human chimeric IgG3wt (wild-type) and IgG4wt as well …

Immunoglobulin G (IgG) concentrates for therapeutic purposes, like passive immunotherapy,
supplementation in inherited or aquired deficiencies or immunomodulation, are prepared …

The unique structure of the human IgG3 constant region with its greatly extended hinge can
clearly be seen in electron micrographs, which compare a series of recombinant proteins …

BACKGROUND Different strategies can be used to improve the tumor: non‐tumor ratio of
radiolabeled antibodies in immunotargeting. One approach is to use secondary antibodies …

In the present study we have characterized a family of anti-dansyl Abs with the variable
region of the heavy chain on human C κ and the variable region of the light chain on …

A matched set of chimeric IgG1 and IgG4 antibodies were used to investigate the role of the
IgG hinge in binding to Ag with differing space between the epitopes. Antibodies bearing …

As part of a systematic effort to determine the features of immunoglobulin E− receptor (IgE−
FcεRI) aggregation that are critical for cellular activation, we used fluorescence to examine …