Insufficient nitric oxide (NO) bioavailability plays an important role in endothelial dysfunction
and arterial stiffening with aging. Supplementation with sodium nitrite, a precursor of NO …

Background Nutrimetabolomics allows for the comprehensive analysis of foods and human
biospecimens to identify biomarkers of intake and begin to probe their associations with …

Background: Metabolomics is emerging as a valuable tool in clinical science. However, one
major challenge in clinical metabolomics is the limited use of standardized guidelines for …

This Feature Article highlights some of the key challenges within the field of metabolomics
and examines what role separation and analytical sciences can play to improve the use of …

In the last decade, metabolomics has experienced significant advances in the throughput
and robustness of analytical methodologies. Yet the preparation of biofluids and low-mass …

Measuring individual circadian phase is important to diagnose and treat circadian rhythm
sleep-wake disorders and circadian misalignment, inform chronotherapy, and advance …

Current metabolite profiling methods based on liquid chromatography-mass spectrometry
(LC-MS) platforms do not detect many of the components present at trace concentrations in …

Objective: The aim of this study was to maximize detection of serum metabolites with high-
resolution metabolomics (HRM). Methods: Department of Defense Serum Repository …

Background Untargeted metabolomics of host-associated samples has yielded insights into
mechanisms by which microbes modulate health. However, data interpretation is challenged …

Recent advancements in separation science have resulted in the commercialization of
multidimensional separation systems that provide higher peak capacities and, hence …