Mechanisms of action of fluvoxamine for COVID-19: a historical review

Y Hashimoto, T Suzuki, K Hashimoto - Molecular psychiatry, 2022 - nature.com
The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) accelerates the discovery of …

COVID-19-related mortality risk in people with severe mental illness: a systematic and critical review

M De Hert, V Mazereel, M Stroobants… - Frontiers in …, 2022 - frontiersin.org
Background: Increasing clinical evidence suggests that people with severe mental illness
(SMI), including schizophrenia spectrum disorders, bipolar disorder (BD), and major …

Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2

TA Tummino, VV Rezelj, B Fischer, A Fischer… - Science, 2021 - science.org
Repurposing drugs as treatments for COVID-19, the disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has drawn much attention. Beginning …

[HTML][HTML] Choosing a cellular model to study SARS-CoV-2

GA Pires De Souza, M Le Bideau, C Boschi… - Frontiers in Cellular …, 2022 - frontiersin.org
As new pathogens emerge, new challenges must be faced. This is no different in infectious
disease research, where identifying the best tools available in laboratories to conduct an …

Association between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID‐19: an observational multicenter study

N Hoertel, M Sánchez‐Rico, E Gulbins… - Clinical …, 2021 - Wiley Online Library
Several medications commonly used for a number of medical conditions share a property of
functional inhibition of acid sphingomyelinase (ASM), or FIASMA. Preclinical and clinical …

Long COVID, neuropsychiatric disorders, psychotropics, present and future

SW Tang, BE Leonard, DM Helmeste - Acta neuropsychiatrica, 2022 - cambridge.org
Long COVID refers to the lingering symptoms which persist or appear after the acute illness.
The dominant long COVID symptoms in the two years since the pandemic began (2020 …

[HTML][HTML] Antidepressant and antipsychotic drugs reduce viral infection by SARS-CoV-2 and fluoxetine shows antiviral activity against the novel variants in vitro

SM Fred, S Kuivanen, H Ugurlu… - Frontiers in …, 2022 - frontiersin.org
Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …

[HTML][HTML] Mechanism of action of small-molecule agents in ongoing clinical trials for SARS-CoV-2: a review

L Zhao, S Li, W Zhong - Frontiers in Pharmacology, 2022 - frontiersin.org
Since the first reports from December 2019, COVID-19 caused an overwhelming global
pandemic that has affected 223 countries, seriously endangering public health and creating …

Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy

JM Brimson, MI Prasanth, DS Malar… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Despite the availability of new vaccines for SARS-CoV-2, there has been slow
uptake and problems with supply in some parts of the world. Hence, there is still a necessity …

[HTML][HTML] Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy

R Batool, M Soler, F Colavita, L Fabeni… - Biosensors and …, 2023 - Elsevier
Monoclonal antibody (mAb) therapy is one of the most promising immunotherapies that have
shown the potential to prevent or neutralize the effects of COVID-19 in patients at very early …