Materials and methods Coronaviruses are classified into four genera: α, β, γ, and δ. All
seven coronaviruses known to cause respiratory infections in humans fall into the α or β …

Sigma-1 receptors are ubiquitous multifunctional ligand-regulated molecular chaperones in
the endoplasmic reticulum membrane with a unique history, structure, and pharmacological …

冠状病毒(coronaviruses, CoVs) 与哺乳类动物的多种疾病的产生有关, 近年来造成了多起人类
呼吸系统传染病的暴发. 目前为止还没有相关治疗药物或疫苗被批准用于治疗冠状病毒 …

Autophagy serves as the primary intracellular degradation mechanism in which damaged
organelles and self-cytoplasmic proteins are transported to the lysosome for degradation …

SARS-CoV-2 entry into host cells is mediated by the Spike (S) protein of the viral envelope.
The S protein is composed of two subunits: S1 that induces binding to the host cell via its …

The ability to accurately determine therapeutic and adverse effects of drugs using
computational means would significantly reduce the failure rate of novel therapeutics in the …

The proteostasis network guarantees successful protein synthesis, folding, transportation,
and degradation. Mounting evidence has revealed that this network maintains proteome …

The novel bioactive peptide AFYRW derived from Tartary buckwheat (Fagopyrum tataricum
Gaertn.) with strong antioxidant capacity was identified in our previous research, but its …

Several human host proteins play important roles in the lifecycle of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2). Many drugs targeting these host proteins have …

Un projet de repositionnement thérapeutique a été développé avec le Prof. S. Jamain
(Institut Mondor de Recherche Biomédicale, Equipe 15), basé sur l'absence de patients …