Oxygen-dependent hydroxylation of hypoxia-inducible factor (HIF)-α subunits by prolyl
hydroxylase domain (PHD) proteins signals their polyubiquitination and proteasomal …

Hypoxia-inducible factors (HIF) mediate metabolic switches in cells in hypoxic environments,
including those in both normal and malignant tissues with limited supplies of oxygen …

Molecular targeting of cancer stem cells (CSCs) has therapeutic potential for efficient
treatment of cancer, although relatively few specific targets have been identified so far …

Relative hypoxia is essential in wound healing since it normally plays a pivotal role in
regulation of all the critical processes involved in tissue repair. Hypoxia-inducible factor …

T cell function and fate can be influenced by several metabolites: in some cases, acting
through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through …

During progression of type 2 diabetes, pancreatic β cells are subjected to sustained
metabolic overload. We postulated that this state mediates a hypoxic phenotype driven by …

OBJECTIVE: Recent evidence suggests that hematopoietic stem cells (HSCs) in the bone
marrow (BM) are located in areas where the environment is hypoxic. Although previous …

Aquatic hypoxia is a frequent event and in fish a complex set of physiological and
biochemical alterations are employed to cope with this environmental stress. Many of these …

Signaling by the peptide ligand apelin and its cognate G protein-coupled receptor APJ has a
potent inotropic effect on cardiac contractility and modulates systemic vascular resistance …

Development of the mammalian heart is governed by precisely orchestrated interactions
between signaling pathways integrating environmental cues and a core cardiac …