Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

The term 'extracellular vesicles' refers to a heterogeneous population of vesicular bodies of
cellular origin that derive either from the endosomal compartment (exosomes) or as a result …

The dynamic interactions of cancer cells with their microenvironment consisting of stromal
cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to …

Multipotent mesenchymal stromal cells (MSCs) ameliorate a wide range of diseases in
preclinical models, but the lack of clarity around their mechanisms of action has impeded …

Exosomes are extracellular vesicles that contain a specific composition of proteins, lipids,
RNA, and DNA. They are derived from endocytic membranes and can transfer signals to …

ABSTRACT KRAS is the most frequently mutated oncogene in human neoplasia. Despite a
large investment to understand the effects of KRAS mutation in cancer cells, the direct effects …

Extracellular vesicles contain a lipid bilayer membrane that protects the encapsulated
material, such as proteins, nucleic acids, lipids and metabolites, from the extracellular …

Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …