Molecular signaling in bone cells: Regulation of cell differentiation and survival

LI Plotkin, A Bruzzaniti - Advances in protein chemistry and structural …, 2019 - Elsevier
The achievement of proper bone mass and architecture, and their maintenance throughout
life requires the concerted actions of osteoblasts, the bone forming cells, and osteoclasts …

[HTML][HTML] Bone effects of mammalian target of rapamycin (mTOR) inhibition with everolimus

P Hadji, R Coleman, M Gnant - Critical reviews in oncology/hematology, 2013 - Elsevier
Patients with breast cancer face substantial challenges to bone health from bone
metastases, as well as from chemotherapy and endocrine therapies that generally elicit …

Major vault protein (MVP) suppresses aging-and estrogen deficiency-related bone loss through Fas-mediated apoptosis in osteoclasts

R Wang, Y Yang, Z Zhang, N Zhao, EAC Wiemer… - Cell death & …, 2023 - nature.com
Osteoclasts (OCs), derived from monocyte/macrophage lineage, are key orchestrators in
bone remodeling. Targeting osteoclast apoptosis is a promising approach to cut down …

Tussilagone promotes osteoclast apoptosis and prevents estrogen deficiency-induced osteoporosis in mice

GH Ryoo, YJ Moon, S Choi, EJ Bae, JH Ryu… - … and biophysical research …, 2020 - Elsevier
Osteoporosis is a degenerative disease characterized by reduced bone mass, in which
deregulated bone remodeling by osteoclasts and osteoblasts is a main pathogenesis …

Essential oils and isolated compounds from Lippia alba leaves and flowers: Antimicrobial activity and osteoclast apoptosis

PJL Juiz, AM Lucchese, R Gambari… - International …, 2015 - spandidos-publications.com
In the present study, essential oils extracted from the leaves and flowers of Lippia alba (Mill.)
NE Br.(L. alba) were analyzed for their antimicrobial activity and their effects on osteoclasts …

Impact of FasL stimulation on sclerostin expression and osteogenic profile in IDG-SW3 osteocytes

A Kratochvilova, A Ramesova, B Vesela, E Svandova… - Biology, 2021 - mdpi.com
Simple Summary FasL used to be considered as a classical ligand triggering cell death
(apoptosis) via its receptor, Fas and thefollowing caspase cascade. As such, it is known to …

Regulation of bone homeostasis: signaling pathways and therapeutic targets

Z Wu, W Li, K Jiang, Z Lin, C Qian, M Wu, Y Xia… - MedComm, 2024 - Wiley Online Library
As a highly dynamic tissue, bone is continuously rebuilt throughout life. Both bone formation
by osteoblasts and bone resorption by osteoclasts constitute bone reconstruction …

FasL Modulates Expression of Mmp2 in Osteoblasts

E Svandova, B Vesela, H Lesot, J Sadoine… - Frontiers in …, 2018 - frontiersin.org
FasL is a well-known actor in the apoptotic pathways but recent reports have pointed to its
important novel roles beyond cell death, as observed also for bone cells. This is supported …

Identification of potentially pathogenic variants associated with recurrence in medication-related osteonecrosis of the jaw (MRONJ) patients using whole-exome …

S Kim, S Mun, W Shin, K Han, MY Kim - Journal of Clinical Medicine, 2022 - mdpi.com
Background: Bisphosphonates are antiresorptive and antiangiogenic drugs that prevent and
treat bone loss and mineralization in women with postmenopausal osteoporosis and cancer …

Levels of selected aqueous humor mediators (IL-10, IL-17, CCL2, VEGF, FasL) in diabetic cataract

S Mitrović, T Kelava, A Šućur… - Ocular immunology and …, 2016 - Taylor & Francis
Purpose: To compare levels of selected mediators in serums and aqueous humor (AH) of
type 2 diabetes mellitus cataract patients with senile cataract patients, and to determine their …