CNS glucose metabolism in Amyotrophic Lateral Sclerosis: a therapeutic target?
TW Tefera, FJ Steyn, ST Ngo, K Borges - Cell & bioscience, 2021 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder
primarily characterized by selective degeneration of both the upper motor neurons in the …
primarily characterized by selective degeneration of both the upper motor neurons in the …
The peripheral immune system and amyotrophic lateral sclerosis
PA McCombe, JD Lee, TM Woodruff… - Frontiers in …, 2020 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease that is defined by
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …
loss of upper and lower motor neurons, associated with accumulation of protein aggregates …
Hypermetabolism is a deleterious prognostic factor in patients with amyotrophic lateral sclerosis
P Jésus, P Fayemendy, M Nicol… - European Journal of …, 2018 - Wiley Online Library
Background and purpose The aim of this study was to investigate patients with amyotrophic
lateral sclerosis in order to determine their nutritional, neurological and respiratory …
lateral sclerosis in order to determine their nutritional, neurological and respiratory …
[HTML][HTML] Skeletal-muscle metabolic reprogramming in ALS-SOD1G93A mice predates disease onset and is a promising therapeutic target
S Scaricamazza, I Salvatori, G Giacovazzo, JP Loeffler… - IScience, 2020 - cell.com
Patients with ALS show, in addition to the loss of motor neurons in the spinal cord,
brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside …
brainstem, and cerebral cortex, an abnormal depletion of energy stores alongside …
Body mass index associates with amyotrophic lateral sclerosis survival and metabolomic profiles
SA Goutman, J Boss, G Iyer, H Habra… - Muscle & …, 2023 - Wiley Online Library
Abstract Introduction/Aims Body mass index (BMI) is linked to amyotrophic lateral sclerosis
(ALS) risk and prognosis, but additional research is needed. The aim of this study was to …
(ALS) risk and prognosis, but additional research is needed. The aim of this study was to …
Altered skeletal muscle glucose–fatty acid flux in amyotrophic lateral sclerosis
FJ Steyn, R Li, SE Kirk, TW Tefera, TY Xie… - Brain …, 2020 - academic.oup.com
Amyotrophic lateral sclerosis is characterized by the degeneration of upper and lower motor
neurons, yet an increasing number of studies in both mouse models and patients with …
neurons, yet an increasing number of studies in both mouse models and patients with …
Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis
ST Ngo, RPA van Eijk, V Chachay… - … lateral sclerosis and …, 2019 - Taylor & Francis
Objective: Weight loss in amyotrophic lateral sclerosis (ALS) is associated with faster
disease progression and shorter survival. It has different possible causes, including loss of …
disease progression and shorter survival. It has different possible causes, including loss of …
Hypermetabolism associated with worse prognosis of amyotrophic lateral sclerosis
J He, J Fu, W Zhao, C Ren, P Liu, L Chen, D Li… - Journal of …, 2022 - Springer
Background and objective Exploration of hypermetabolism in amyotrophic lateral sclerosis
(ALS) with different ethnicities is needed to understand its metabolic implications for clinical …
(ALS) with different ethnicities is needed to understand its metabolic implications for clinical …
Fat mass loss correlates with faster disease progression in amyotrophic lateral sclerosis patients: Exploring the utility of dual-energy x-ray absorptiometry in a …
I Lee, M Kazamel, T McPherson, J McAdam… - PLoS …, 2021 - journals.plos.org
Background/objective Weight loss is a predictor of shorter survival in amyotrophic lateral
sclerosis (ALS). We performed serial measures of body composition using Dual-energy X …
sclerosis (ALS). We performed serial measures of body composition using Dual-energy X …
Lower hypothalamic volume with lower body mass index is associated with shorter survival in patients with amyotrophic lateral sclerosis
J Chang, TB Shaw, CJ Holdom… - European Journal of …, 2023 - Wiley Online Library
Background and purpose Weight loss in patients with amyotrophic lateral sclerosis (ALS) is
associated with faster disease progression and shorter survival. Decreased hypothalamic …
associated with faster disease progression and shorter survival. Decreased hypothalamic …