The culture of Chinese Hamster Ovary (CHO) cells for modern industrial applications, such
as expression of recombinant proteins, requires media that support growth and production …

Chinese hamster ovary (CHO) cells represent the most frequently applied host cell system
for industrial manufacturing of recombinant protein therapeutics. CHO cells are capable of …

While the rapid development of COVID-19 vaccines has been a scientific triumph, the need
remains for a globally available vaccine that provides longer-lasting immunity against …

From 2006 to 2011, an average of 15 novel recombinant protein therapeutics have been
approved by US Food and Drug Administration (FDA) annually. In addition, the expiration of …

Mammalian protein production platforms have had a profound impact in many areas of basic
and applied research, and an increasing number of blockbuster drugs are recombinant …

Recombinant proteins, such as monoclonal antibodies, are produced in mammalian cell
lines to introduce proper protein folding and posttranslational modifications, which are …

Highlights•The CHO genome suffers from chromosomal rearrangements and other stability-
related issues.•The CHO cell instability phenotype is characterized by titer instability and …

Intracellular tumor antigens presented on the cell surface in the context of human leukocyte
antigen (HLA) molecules have been targeted by T cell–based therapies, but there has been …

Metabolic programs are known to be altered in cancers arising from various tissues.
Malignant transformation can alter signaling pathways related to metabolism and increase …

The glutamine synthetase (GS)-based Chinese hamster ovary (CHO) selection system is an
attractive approach to efficiently identify suitable clones in the cell line generation process …