Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

Ketamine is an effective antidepressant, but there is substantial variability in patient
response and the precise mechanism of action is unclear. Neuroimaging can provide …

Quantifying neural activity in natural conditions (ie conditions comparable to the standard
clinical patient experience) during the administration of psychedelics may further our …

Intravenous ketamine is posited to rapidly reverse depression by rapidly enhancing
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …

Conventional monoamine-based pharmacotherapy, considered the first-line treatment for
major depressive disorder (MDD), has several challenges, including high rates of non …

Ketamine offers promising new therapeutic options for difficult-to-treat depression. The
efficacy of treatment response, including ketamine, has been intricately linked to EEG …

Abstract Background Lily Bulb and Rehmannia Decoction (LBRD), is a traditional Chinese
formula that has been shown to be safe and effective against depression; however, its …

Introduction Deficiencies in standard of care antidepressants are driving novel drug
discovery. A new age of antidepressant medications has emerged with the introduction of …

Ketamine produces fast‐acting antidepressant effects in treatment resistant depression
(TRD). Though prior studies report ketamine‐related changes in brain activity in TRD …

Research over the last two decades has established ketamine as a safe, effective, fast-
acting, and sustained antidepressant that significantly reduces adverse symptoms …