Abstract P2Y12, the Gi-coupled platelet receptor for adenosine diphosphate (ADP), plays a
central role in platelet function. Patients with congenital P2Y12 defects display a mild to …

Background...... 129 Carotid Artery Disease...... 130 Neurovascular Anatomy and
Physiology...... 130 Pathology and Pathophysiology...... 132 Natural History and Risk …

Aspirin (various doses) not stated 17%(P= 0.001) reduction in serious vascular events;
36%(P= 0.003) reduction in nonfatal MI; 21%(P= 0.01) reduction in major coronary events; …

Aims We assessed the effect of concomitant aspirin use on the efficacy and safety of
apixaban compared with warfarin in patients with atrial fibrillation (AF). Methods and results …

BACKGROUND: Results of trials of aspirin and dipyridamole combined versus aspirin alone
for the secondary prevention of vascular events after ischaemic stroke of presumed arterial …

Aims To assess the incidence, timing, and relation of drug-eluting stent (DES) thrombosis to
discontinuation of clopidogrel therapy. Methods and results This prospective observational …

Stroke affects more than 700,000 in-dividuals each year; it is the third largest cause of death
and the largest cause of adult disability in the US Diabetes is a major risk factor for the …

Background—It is widely supposed, but not well-demonstrated, that cumulative advances in
standard care have reduced recurrent stroke and cardiovascular events in secondary …

Objective: A literature review of antiplatelet agents for primary and secondary stroke
prevention, including mechanism of action, cost, and reasons for lack of benefit. Data …

Background—This study evaluated the risk of upper gastrointestinal bleeding (UGIB)
associated with use of low-dose acetylsalicylic acid (ASA) alone and in combination with …