Overview of mass spectrometry-based metabolomics: opportunities and challenges

GAN Gowda, D Djukovic - Mass Spectrometry in Metabolomics: Methods …, 2014 - Springer
The field of metabolomics has witnessed an exponential growth in the last decade driven by
important applications spanning a wide range of areas in the basic and life sciences and …

[HTML][HTML] Applications of machine learning in metabolomics: Disease modeling and classification

A Galal, M Talal, A Moustafa - Frontiers in genetics, 2022 - frontiersin.org
Metabolomics research has recently gained popularity because it enables the study of
biological traits at the biochemical level and, as a result, can directly reveal what occurs in a …

[HTML][HTML] Metabolite discovery: Biochemistry's scientific driver

M Giera, O Yanes, G Siuzdak - Cell metabolism, 2022 - cell.com
Metabolite identification represents a major challenge, and opportunity, for biochemistry.
The collective characterization and quantification of metabolites in living organisms, with its …

New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era

NL Kuehnbaum, P Britz-McKibbin - Chemical reviews, 2013 - ACS Publications
Metabolomics offers a revolutionary framework for phenotyping individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Plant metabolomics: large-scale phytochemistry in the functional genomics era

LW Sumner, P Mendes, RA Dixon - Phytochemistry, 2003 - Elsevier
Metabolomics or the large-scale phytochemical analysis of plants is reviewed in relation to
functional genomics and systems biology. A historical account of the introduction and …

ANOVA-simultaneous component analysis (ASCA): a new tool for analyzing designed metabolomics data

AK Smilde, JJ Jansen, HCJ Hoefsloot… - …, 2005 - academic.oup.com
Motivation: Datasets resulting from metabolomics or metabolic profiling experiments are
becoming increasingly complex. Such datasets may contain underlying factors, such as time …

The versatile use of exhaled volatile organic compounds in human health and disease

AW Boots, JJBN van Berkel, JW Dallinga… - Journal of breath …, 2012 - iopscience.iop.org
Exhaled breath contains thousands of volatile organic compounds (VOCs) of which the
composition varies depending on health status. Various metabolic processes within the …

Mass spectrometry in metabolome analysis

SG Villas‐Bôas, S Mas, M Åkesson… - Mass spectrometry …, 2005 - Wiley Online Library
In the post‐genomic era, increasing efforts have been made to describe the relationship
between the genome and the phenotype in cells and organisms. It has become clear that …

Metabolomics technology and bioinformatics

V Shulaev - Briefings in bioinformatics, 2006 - academic.oup.com
Metabolomics is the global analysis of all or a large number of cellular metabolites. Like
other functional genomics research, metabolomics generates large amounts of data …

Regulatory enzymes of mitochondrial β‐oxidation as targets for treatment of the metabolic syndrome

M Schreurs, F Kuipers, FR Van Der Leij - obesity reviews, 2010 - Wiley Online Library
Insulin sensitizers like metformin generally act through pathways triggered by adenosine
monophosphate‐activated protein kinase. Carnitine palmitoyltransferase 1 (CPT1) controls …