Epithelial permeability is a hallmark of mucosal inflammation, but the molecular mechanisms
involved remain poorly understood. A key component of the epithelial barrier is the apical …

The pathogenesis of asthma includes a complex interplay among airway inflammation,
hyperresponsiveness, and remodeling. Current evidence suggests that airway structural …

Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern.
Because of this, most research has focused on investigating the role of allergic pathways …

Current asthma therapy is based on the use of adrenergic bronchodilator and anti-
inflammatory drugs the specificity, efficacy, duration of action, and safety of which have been …

Abstract Background Eosinophilic esophagitis (EoE) exhibits esophageal dysfunction owing
to an eosinophil‐predominant inflammation. Activated eosinophils generate eosinophil …

Asthma is an inflammatory disorder of the airways, characterized by infiltration of mast cells,
eosinophils, and Th2-type CD4+ T cells in the airway wall. Airway epithelium constitutes the …

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by both a chronic
inflammation and tissue remodelling; as indicated by extracellular matrix protein deposition …

Airway epithelial cells are the first line of defense against the constituents of the inhaled air,
which include allergens, pathogens, pollutants, and toxic compounds. The epithelium not …

Small airways (< 2 mm in diameter) are probably involved across almost all asthma
severities and they show proportionally more structural and functional abnormalities with …

The bronchial epithelium is continuously exposed to a multitude of noxious challenges in
inhaled air. Cellular contact with most damaging agents is reduced by the action of the …