Asthma is an allergic airway inflammatory disease characterized by type 2 immune
responses. Growing evidence suggests an association between allergic airways and …

The epithelium of asthmatics is characterized by reduced expression of E-cadherin and
increased expression of the basal cell markers ck-5 and p63 that is indicative of a relatively …

Abstract Background microRNA (miR)‐218‐5p is involved in cigarette smoke‐induced
airway inflammation. In our earlier asthma epithelial miRNA profiling data, miR‐218‐5p was …

Background The standard approach to determine unique or shared genetic factors across
populations is to identify risk alleles in one population and investigate replication in others …

Radix Astragali, has long been used to alleviate allergic diseases (ADs). Formononetin is
one of the major active components in Radix Astragali, but its mechanism on ADs is not …

Since their identification as a unique cell population, innate lymphoid cells (ILCs) have
revolutionized our understanding of immune responses, leaving their impact on multiple …

The predominant function of the skin is to serve as a barrier—to protect against external
insults and to prevent water loss. Junctional and structural proteins in the stratum corneum …

Type 2 inflammation is a complex immune response and primary mechanism for several
common allergic diseases including allergic rhinitis, allergic asthma, atopic dermatitis, and …

Background Gene expression changes in the structural cells of the airways are thought to
play a role in the development of asthma and airway hyperresponsiveness. This includes …

Though asthma is a common and relatively easy to diagnose disease, attempts at primary or
secondary prevention, and cure, have been disappointing. The widespread use of inhaled …