Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

Glucocorticoid hormones (cortisol and corticosterone-CORT) are the effector hormones of
the hypothalamic-pituitary-adrenal (HPA) axis neuroendocrine system. CORT is a systemic …

Microglia are the only immune cells that permanently reside in the central nervous system
(CNS) alongside neurons and other types of glial cells. The past decade has witnessed a …

The population of aged individuals is increasing worldwide and this has significant health
and socio-economic implications. Clinical and experimental studies on aging have …

More than one-third of American adults are obese and statistics are similar worldwide.
Caloric intake and diet composition have large and lasting effects on cognition and emotion …

A consequence of normal aging is a greater susceptibility to memory impairments following
an immune challenge such as infection, surgery, or traumatic brain injury. The …

The rate of age-associated cognitive decline varies considerably between individuals. It is
important, both on a societal and individual level, to investigate factors that underlie these …

Amplified neuroinflammatory responses following an immune challenge occur with normal
aging and can elicit or exacerbate neuropathology. The mechanisms mediating this …

Among all major organs, the brain is one of the most susceptible to the inexorable effects of
aging. Throughout the last decades, several studies in human cohorts and animal models …

Exposure to stressors can enhance neuroinflammatory responses, and both stress and
neuroinflammation are predisposing factors in the development of psychiatric disorders …