An insight into FDA approved antibody-drug conjugates for cancer therapy
The large number of emerging antibody-drug conjugates (ADCs) for cancer therapy has
resulted in a significant market 'boom', garnering worldwide attention. Despite ADCs …
resulted in a significant market 'boom', garnering worldwide attention. Despite ADCs …
Antibody–drug conjugates: a comprehensive review
Antibody–drug conjugates (ADC) are one of the fastest growing anticancer drugs. This
approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …
approach comprises a mAb conjugated to the cytotoxic payload via a chemical linker that …
Paclitaxel: application in modern oncology and nanomedicine‐based cancer therapy
J Sharifi-Rad, C Quispe, JK Patra… - Oxidative medicine …, 2021 - Wiley Online Library
Paclitaxel is a broad‐spectrum anticancer compound, which was derived mainly from a
medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a …
medicinal plant, in particular, from the bark of the yew tree Taxus brevifolia Nutt. It is a …
Antibody–drug conjugates for cancer
CH Chau, PS Steeg, WD Figg - The Lancet, 2019 - thelancet.com
Antibody–drug conjugates (ADCs) are immunoconjugates comprised of a monoclonal
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
antibody tethered to a cytotoxic drug (known as the payload) via a chemical linker. The ADC …
The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …
Molecular targeted therapy: Treating cancer with specificity
Molecular targeted therapies are revolutionized therapeutics which interfere with specific
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …
molecules to block cancer growth, progression, and metastasis. Many molecular targeted …
[HTML][HTML] Biologics vs. small molecules: Drug costs and patient access
FD Makurvet - Medicine in Drug Discovery, 2021 - Elsevier
Significant advances in drug research and development are herein reviewed first to set the
background for a critical consideration of the economic sustainability of biologics and small …
background for a critical consideration of the economic sustainability of biologics and small …
Mechanisms of ADC toxicity and strategies to increase ADC tolerability
TD Nguyen, BM Bordeau, JP Balthasar - Cancers, 2023 - mdpi.com
Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …
The evolving landscape of antibody–drug conjugates: In depth analysis of recent research progress
Antibody–drug conjugates (ADCs) are targeted immunoconjugate constructs that integrate
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …
the potency of cytotoxic drugs with the selectivity of monoclonal antibodies, minimizing …