Immunohistochemistry is an essential component of diagnostic breast pathology. The
emergence of novel assays and applications is accompanied by new interpretation criteria …

Abstract GATA binding protein 3 (GATA3) belongs to a family of transcription factors
comprising six members. These proteins identify GATA containing sequences in the target …

Explaining the genetics of many diseases is challenging because most associations localize
to incompletely characterized regulatory regions. Using new computational methods, we …

MicroRNA-mediated post-transcriptional regulation plays key roles in stem cell self-renewal
and tumorigenesis. However, the in vivo functions of specific microRNAs in controlling …

Purpose: Functional loss of BRCA1 is associated with poorly differentiated and metastatic
breast cancers that are enriched with cancer stem cells (CSCs). CSCs can be generated …

TRPS1 has been recently demonstrated as a highly sensitive and specific marker for breast
carcinomas. To further explore TRPS1's utility in breast carcinoma, we systematically …

Basal-like breast cancers (BLBCs) are among the most aggressive cancers, partly due to
their enrichment of cancer stem cells (CSCs). Breast CSCs can be generated from luminal …

Background Metastatic breast carcinoma is commonly considered during differential
diagnosis when metastatic disease is detected in females. In addition to the tumor …

Purpose Despite numerous studies on the utility of GATA-3 as breast cancer marker, its
comparison with other breast markers, its concordance between primary and metastatic …

Melatonin mitigates cancer initiation, progression and metastasis through inhibition of both
the synthesis of estrogens and the transcriptional activity of the estradiol-ER (Estrogen …