Anaesthetic-related neuroprotection: intravenous or inhalational agents?

D Schifilliti, G Grasso, A Conti, V Fodale - CNS drugs, 2010 - Springer
In designing the anaesthetic plan for patients undergoing surgery, the choice of anaesthetic
agent may often appear irrelevant and the best results obtained by the use of a technique or …

Alzheimer's disease and post-operative cognitive dysfunction

Z Xie, RE Tanzi - Experimental gerontology, 2006 - Elsevier
Alzheimer's disease (AD), an insidious and progressive neurodegenerative disorder
accounting for the vast majority of dementia, is characterized by global cognitive decline and …

The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid β protein levels

Z Xie, Y Dong, U Maeda, P Alfille, DJ Culley… - The Journal of the …, 2006 - pubs.asahq.org
Background The common inhalation anesthetic isoflurane has previously been reported to
enhance the aggregation and cytotoxicity of the Alzheimer disease-associated amyloid beta …

Preconditioning with isoflurane produces dose-dependent neuroprotection via activation of adenosine triphosphate-regulated potassium channels after focal cerebral …

L Xiong, Y Zheng, M Wu, L Hou, Z Zhu… - Anesthesia & …, 2003 - journals.lww.com
In this study, we determined whether repeated brief isoflurane (Iso) anesthesia induces
ischemic tolerance to focal cerebral ischemia in a dose-response manner and whether the …

Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain

H Kitano, JR Kirsch, PD Hurn… - Journal of Cerebral …, 2007 - journals.sagepub.com
This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia
and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and …

Neuroprotective gases–fantasy or reality for clinical use?

J Deng, C Lei, Y Chen, Z Fang, Q Yang, H Zhang… - Progress in …, 2014 - Elsevier
The neuroprotective properties for certain medical gases have been observed for decades,
leading to extensive research that has been widely reported and continues to garner …

Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia

S Bercker, B Bert, P Bittigau, U Felderhoff-Müser… - Neurotoxicity …, 2009 - Springer
Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of
newborn rats to a variety of anesthetics has been shown to induce apoptotic …

Comparison of behavioral deficits and acute neuronal degeneration in rat lateral fluid percussion and weight-drop brain injury models

TM Hallam, CL Floyd, MM Folkerts, LL Lee… - Journal of …, 2004 - liebertpub.com
The behavioral and histological effects of the lateral fluid percussion (LFP) brain injury
model were compared with the weight drop impact-acceleration model with 10 min of …

Isoflurane posttreatment reduces neonatal hypoxic–ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway

Y Zhou, T Lekic, N Fathali, RP Ostrowski, RD Martin… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—Isoflurane, administered before or during cerebral ischemia, has
been shown to exhibit neuroprotection in animal models of ischemic stroke. However, the …

The importance of the excitatory amino acid transporter 3 (EAAT3)

WE Bjørn-Yoshimoto, SM Underhill - Neurochemistry international, 2016 - Elsevier
The neuronal excitatory amino acid transporter 3 (EAAT3) is fairly ubiquitously expressed in
the brain, though it does not necessarily maintain the same function everywhere. It is …