Anaesthetic-related neuroprotection: intravenous or inhalational agents?
In designing the anaesthetic plan for patients undergoing surgery, the choice of anaesthetic
agent may often appear irrelevant and the best results obtained by the use of a technique or …
agent may often appear irrelevant and the best results obtained by the use of a technique or …
Alzheimer's disease and post-operative cognitive dysfunction
Alzheimer's disease (AD), an insidious and progressive neurodegenerative disorder
accounting for the vast majority of dementia, is characterized by global cognitive decline and …
accounting for the vast majority of dementia, is characterized by global cognitive decline and …
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid β protein levels
Background The common inhalation anesthetic isoflurane has previously been reported to
enhance the aggregation and cytotoxicity of the Alzheimer disease-associated amyloid beta …
enhance the aggregation and cytotoxicity of the Alzheimer disease-associated amyloid beta …
Preconditioning with isoflurane produces dose-dependent neuroprotection via activation of adenosine triphosphate-regulated potassium channels after focal cerebral …
L Xiong, Y Zheng, M Wu, L Hou, Z Zhu… - Anesthesia & …, 2003 - journals.lww.com
In this study, we determined whether repeated brief isoflurane (Iso) anesthesia induces
ischemic tolerance to focal cerebral ischemia in a dose-response manner and whether the …
ischemic tolerance to focal cerebral ischemia in a dose-response manner and whether the …
Inhalational anesthetics as neuroprotectants or chemical preconditioning agents in ischemic brain
H Kitano, JR Kirsch, PD Hurn… - Journal of Cerebral …, 2007 - journals.sagepub.com
This review will focus on inhalational anesthetic neuroprotection during cerebral ischemia
and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and …
and inhalational anesthetic preconditioning before ischemic brain injury. The limitations and …
Neuroprotective gases–fantasy or reality for clinical use?
J Deng, C Lei, Y Chen, Z Fang, Q Yang, H Zhang… - Progress in …, 2014 - Elsevier
The neuroprotective properties for certain medical gases have been observed for decades,
leading to extensive research that has been widely reported and continues to garner …
leading to extensive research that has been widely reported and continues to garner …
Neurodegeneration in newborn rats following propofol and sevoflurane anesthesia
S Bercker, B Bert, P Bittigau, U Felderhoff-Müser… - Neurotoxicity …, 2009 - Springer
Propofol and sevoflurane are commonly used drugs in pediatric anesthesia. Exposure of
newborn rats to a variety of anesthetics has been shown to induce apoptotic …
newborn rats to a variety of anesthetics has been shown to induce apoptotic …
Comparison of behavioral deficits and acute neuronal degeneration in rat lateral fluid percussion and weight-drop brain injury models
TM Hallam, CL Floyd, MM Folkerts, LL Lee… - Journal of …, 2004 - liebertpub.com
The behavioral and histological effects of the lateral fluid percussion (LFP) brain injury
model were compared with the weight drop impact-acceleration model with 10 min of …
model were compared with the weight drop impact-acceleration model with 10 min of …
Isoflurane posttreatment reduces neonatal hypoxic–ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway
Y Zhou, T Lekic, N Fathali, RP Ostrowski, RD Martin… - Stroke, 2010 - Am Heart Assoc
Background and Purpose—Isoflurane, administered before or during cerebral ischemia, has
been shown to exhibit neuroprotection in animal models of ischemic stroke. However, the …
been shown to exhibit neuroprotection in animal models of ischemic stroke. However, the …
The importance of the excitatory amino acid transporter 3 (EAAT3)
WE Bjørn-Yoshimoto, SM Underhill - Neurochemistry international, 2016 - Elsevier
The neuronal excitatory amino acid transporter 3 (EAAT3) is fairly ubiquitously expressed in
the brain, though it does not necessarily maintain the same function everywhere. It is …
the brain, though it does not necessarily maintain the same function everywhere. It is …