[HTML][HTML] Exploring immune-related pathogenesis in lung injury: Providing new insights Into ALI/ARDS

J Zheng, Y Li, X Kong, J Guo - Biomedicine & Pharmacotherapy, 2024 - Elsevier
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represent a
significant global burden of morbidity and mortality, with lung injury being the primary cause …

NLRC3 participates in inhibiting the pulmonary inflammatory response of sepsis-induced acute lung injury

R Li, Y Zhao, X Zhang, L Yang, X Zou - Immunological …, 2023 - Taylor & Francis
Acute lung injury (ALI) progresses rapidly, is difficult to treat, and has a high fatality rate. The
excessive inflammatory response is an important pathological mechanism of ALI. NLRC3 …

ACT001 suppressing M1 polarization against inflammation via NF-κB and STAT1 signaling pathways alleviates acute lung injury in mice

H Guo, Y Song, F Li, Y Fan, Y Li, C Zhang… - International …, 2022 - Elsevier
ACT001 has been shown to exhibit excellent antitumor and anti-fibrosis activities. However,
the role of ACT001 in acute lung injury (ALI) and the underlying mechanism remains largely …

[HTML][HTML] Pyroptosis in septic lung injury: interactions with other types of cell death

Y Jiang, S Gao, Z Chen, X Zhao, J Gu, H Wu… - Biomedicine & …, 2023 - Elsevier
Sepsis is a life-threatening systemic inflammatory response syndrome caused by the host
imbalanced response to infection. Lung injury is the most common complication of sepsis …

Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy

C Lu, J Zheng, Y Ding, Y Meng, F Tan, W Gong… - Drug …, 2021 - Taylor & Francis
Acute lung injury (ALI) is a disease associated with suffering and high lethality, but to date
without any effective pharmacological management in the clinic. In the pathological …

Cinobufagin alleviates lipopolysaccharide-induced acute lung injury by regulating autophagy through activation of the p53/mTOR pathway

C Wang, X Mei, Y Wu, Y Yang, Z Zeng - Frontiers in Pharmacology, 2022 - frontiersin.org
Acute lung injury (ALI) is a severe clinical disorder characterized by dysregulated
inflammatory responses, leading to high rates of morbidity and mortality. Cinobufagin, a …

CircN4bp1 facilitates sepsis‐induced acute respiratory distress syndrome through mediating macrophage polarization via the miR‐138‐5p/EZH2 Axis

D Zhao, C Wang, X Liu, N Liu, S Zhuang… - Mediators of …, 2021 - Wiley Online Library
We recently reported the differential circRNA expression patterns of the pulmonary
macrophages in sepsis‐induced acute respiratory distress syndrome (ARDS) mice model by …

Administration of protopine prevents mitophagy and acute lung injury in sepsis

Z Xiao, J Long, J Zhang, Z Qiu, C Zhang… - Frontiers in …, 2023 - frontiersin.org
Introduction: Sepsis is a severe life-threatening infection that induces a series of
dysregulated physiologic responses and results in organ dysfunction. Acute lung injury …

A novel antivirulent compound fluorothiazinone inhibits Klebsiella pneumoniae biofilm in vitro and suppresses model pneumonia

SV Tsarenko, NA Zigangirova, AV Soloveva… - The Journal of …, 2023 - nature.com
The problematic treatment of infections caused by multiple-resistant Klebsiella, especially in
ICU, is the leading cause of prolonged hospitalization and high mortality rates. The use of …

Pinelliae rhizoma alleviated acute lung injury induced by lipopolysaccharide via suppressing endoplasmic reticulum stress-mediated NLRP3 inflammasome

N Wang, X Zhang, P Shen, C Huang, H Deng… - Frontiers in …, 2022 - frontiersin.org
Pinelliae rhizoma (PR), one kind of commonly-used Chinese herbs, is generally prescribed
to treat various respiratory diseases, including acute lung injury (ALI). However, the accurate …