A systematic review and random-effects model network meta-analysis were conducted to
compare the efficacy, acceptability, tolerability, and safety of antidepressants to treat adults …

Background Although antipsychotic maintenance treatment is widely recommended to
prevent relapse in chronic psychoses, evidence-based guidelines do not provide clear …

Background Side-effects of psychiatric medication impair quality of life and functioning.
Furthermore, they contribute to morbidity, mortality, stigma, and poor treatment concordance …

Most acute phase antipsychotic drug trials in schizophrenia last only a few weeks, but
patients must usually take these drugs much longer. We examined the long‐term efficacy of …

Background Schizophrenia is a severe psychiatric disorder with periods of remission and
relapse. As discontinuation of antipsychotic medication is the most important reason for …

Importance Generalized anxiety disorder (GAD) is one of the most common mental disorders
in adults. Psychotherapies are among the most recommended treatments for GAD, but which …

Patients with schizophrenia experience a broad range of detrimental health outcomes
resulting from illness severity, heterogeneity of disease, lifestyle behaviors, and adverse …

Alternatives to traditional categorical diagnoses have been proposed to improve the validity
and utility of psychiatric nosology. This paper continues the companion review of an …

We hypothesized that shifting from oral second-generation antipsychotics (SGA) to their long-
acting injectable (LAI) counterpart would be beneficial for the psychopathological, cognitive …

Evidence on long-acting antipsychotics (LAIs) in unselected populations with severe mental
illness is scant. In this mirror-image study, we compared multiple clinical outcomes 1 year …