Bioluminescence reactions are widely applied in optical in vivo imaging in the life science
and medical fields. Such reactions produce light upon the oxidation of a luciferin (substrate) …

Bioluminescence-based probes have long been used to quantify and visualize biological
processes in vitro and in vivo. Over the past years, we have witnessed the trend of …

Chemiluminescence is a remarkable process in which light is emitted due to a chemical
reaction, without the need for photoexcitation. Among some of the most well-known …

Chemi-and bioluminescence are remarkable light-emitting phenomena, in which thermal
energy is converted into excitation energy due to a (bio) chemical reaction. Among a wide …

NanoLuc (NLuc) is an artificial coelenterazine-dependent luciferase generated from the
deep-sea shrimp Oplophorus gracilirostris. Its peculiar properties─ small size and long …

Superoxide anion is a reactive oxygen species (ROS) of biological interest. More
specifically, it plays a role in intra-and intercellular signaling, besides being associated with …

Marine Coelenterazine is one of the most well-known chemi-/bioluminescent systems, and
in which reaction the chemi-/bioluminophore (Coelenteramide) is generated and …

Ca2+-triggered coelenterazine-binding protein (CBP) is a natural form of the luciferase
substrate involved in the Renilla bioluminescence reaction. It is a stable complex of …

Reactive oxygen species (ROS), including superoxide anion, are involved in regulating
various signaling pathways and are also responsible for oxidative stress. Sensing …

Optical imaging including fluorescence and luminescence is the most popular method for
the in vivo imaging in mice. Luminescence imaging is considered to be superior to …