The glycosaminoglycan hyaluronan (HA), a major component of extracellular matrices, and
cell surface receptors of HA have been proposed to have pivotal roles in cell proliferation …

The inflammatory chemokines CXCL9, CXCL10, and CXCL11 are predominantly induced
by interferon (IFN)-γ and share an exclusive chemokine receptor named CXC chemokine …

Leukocyte migration into tissues depends on the activity of chemokines that form
concentration gradients to guide leukocytes to a specific site. Interaction of chemokines with …

Transition from homeostatic to reactive matrix remodeling is a fundamental adaptive tissue
response to injury, inflammatory disease, fibrosis, and cancer. Alterations in architecture …

Airway epithelium is emerging as a regulator of innate immune responses to a variety of
insults including cigarette smoke. The main goal of this study was to explore the effects of …

Diseases of mucosal inflammation represent important causes of morbidity and mortality,
and have led to Intense research efforts to understand the factors that lead to their …

Allergic contact dermatitis (ACD) is an important occupational and environmental disease
caused by topical exposure to chemical allergens. It describes the adverse effects that may …

Background Altered pulmonary defenses in chronic obstructive pulmonary disease (COPD)
may promote distal airways bacterial colonization. The expression/activation of Toll Like …

Introduction Mechanical ventilation with even moderate-sized tidal volumes synergistically
increases lung injury in sepsis and has been associated with proinflammatory low-molecular …

Hyaluronic acid (HA) is a major component of the extracellular matrix. It is synthesized by
hyaluronan synthases (HAS) into high-molecular-weight chains (HMW-HA) that exhibit anti …