Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Both inflammasomes and autophagy have important roles in the intracellular homeostasis,
inflammation, and pathology; the dysregulation of these processes is often associated with …

To prevent visual loss, clinical therapy of severe bacterial keratitis (BK) demands
simultaneous remedying of the damage caused by bacterial infection and its induced …

Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is
the major constituent of the outer membrane of gram-negative bacteria. Endothelial cells …

The inflammasome is a large intracellular protein complex that activates inflammatory
caspase-1 and induces the maturation of interleukin (IL)-1β and IL-18. Mitophagy plays an …

The mechanisms of inflammation in bone and joint tissue are complex and involve long non‑
coding RNAs (lncRNAs), which play an important role in this process. The aim of the present …

Mitochondria have several quality control mechanisms by which they maintain cellular
homeostasis and ensure that the molecular machinery is protected from stress. Mitophagy …

As an acute ophthalmic infection, bacterial keratitis (BK) can lead to severe visual morbidity,
such as corneal perforation, intraocular infection, and permanent corneal opacity, if rapid …

Mycobacterium tuberculosis (Mtb) employs plethora of mechanisms to hijack the host
defence machinery for its successful survival, proliferation and persistence. Here, we show …