Antibodies have long been viewed as potential agents for targeted drug delivery and other
therapeutic interventions, largely with a view to exploiting the combination of high specificity …

Toxic lectins, plant proteins that inactivate ribosomes, irreversibly inhibit protein synthesis
with high efficiency. After intraneural (subepineurial) microinjection, these agents are taken …

Abstract MA Poli, VR Rivera, JF Hewetson and GA Merrill. Detection of ricin by colorimetric
and chemiluminescence ELISA. Toxicon32, 1371–1377, 1994.—A highly sensitive and …

Background: β-bungarotoxin is a heterodimeric neurotoxin consisting of a phospholipase
subunit linked by a disulfide bond to a K+ channel binding subunit which is a member of the …

Upon intravenous injection into rats, the plant toxin ricin was rapidly cleared from the
circulation by the liver. Among the different liver cell populations, most of the injected ricin …

Bryodin 1 (BD1) is a potent ribosome-inactivating protein (RIP) isolated from the plant
Bryonia dioica. It is relatively nontoxic in rodents (LD50> 40 mg/kg) and represents a …

A sensitive and specific enzyme-linked immunoadsorbent assay (ELISA) was developed to
detect ricin in biological fluids. The assay is based on the sandwich format using monoclonal …

The advent of monoclonal antibodies has revitalised the concept of magic bullets and
various agents (eg. drugs, toxins and isotopes) have been conjugated to monoclonal …

Success in the generation of an antibody-based therapeutic requires careful consideration
of the binding site, to achieve specificity and high affinity; of the effector, to produce the …

A selection of galactose and lactose analogues was evaluated for their potency in inhibiting
the binding of ricin to immobilised asialofetuin, which is a model of the cell-surface receptor …